Characterizing absence epileptic seizures from depth cortical measurements

In this paper, we are going to localize the onset regions and investigate the dynamics of absence epileptic seizures using local field potential recording by depth electrode. We assume that there are some hidden states (under Markovian model) during the seizure and each spike of the seizure is generated when one of the states is activated. Each state is considered as the linear superposition of a few epileptic activities (substates) and each epileptic activity is described by two characteristics: 1) the spatial topography and 2) the temporal representation. Experimental results demonstrate the generality of the proposed model in characterizing absence epileptic seizures.

[1]  R. Quian Quiroga,et al.  Unsupervised Spike Detection and Sorting with Wavelets and Superparamagnetic Clustering , 2004, Neural Computation.

[2]  Frédérique Amor,et al.  Cortical local and long-range synchronization interplay in human absence seizure initiation , 2009, NeuroImage.

[3]  Stefano Panzeri,et al.  Modelling and analysis of local field potentials for studying the function of cortical circuits , 2013, Nature Reviews Neuroscience.

[4]  Lawrence R. Rabiner,et al.  A tutorial on hidden Markov models and selected applications in speech recognition , 1989, Proc. IEEE.

[5]  Klas H. Pettersen,et al.  Current-source density estimation based on inversion of electrostatic forward solution: Effects of finite extent of neuronal activity and conductivity discontinuities , 2006, Journal of Neuroscience Methods.

[6]  Jean Gotman,et al.  Dynamic analysis of absence seizures in humans: all the same but all different , 2010 .

[7]  Christian Jutten,et al.  Dynamical analysis of brain seizure activity from EEG signals , 2014, 2014 22nd European Signal Processing Conference (EUSIPCO).

[8]  Olivier Meste,et al.  Time Delay Estimation: A New Insight Into the Woody's Method , 2008, IEEE Signal Processing Letters.

[9]  S. Charpier,et al.  Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures , 2007, The Journal of Neuroscience.

[10]  F. H. Lopes da Silva,et al.  Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats , 2002, The Journal of Neuroscience.