Recently, foundational mathematical theory, compressed sensing (CS), has been developed which enables accurate reconstruction from greatly undersampled frequency information (Candes et. al. and Donoho). Using numerical phantoms it has been demonstrated that CS reconstruction (e.g. minimizing the ℓ1 norm of the discrete gradient of the image) offers promise for computed tomography. However, when using experimental CT projection data the undersampling factors enabled were smaller than in numerical simulations. An extension to CS has recently been proposed wherein a prior image is utilized as a constraint in the image reconstruction procedure (i.e. Prior Image Constrained Compressed Sensing - PICCS). Experimental results are demonstrated here from a clinical C-arm system, highlighting one application of PICCS in reducing radiation exposure during interventional procedures while preserving high image quality. In this study a range of view angles has been investigated from very limited angle aquisitions (e.g. tomosythesis) to undersampled CT acquisitions.