Parkinsonian tremor identification with multiple local field potential feature classification

This paper explores the development of multi-feature classification techniques used to identify tremor-related characteristics in the Parkinsonian patient. Local field potentials were recorded from the subthalamic nucleus and the globus pallidus internus of eight Parkinsonian patients through the implanted electrodes of a Deep brain stimulation (DBS) device prior to device internalization. A range of signal processing techniques were evaluated with respect to their tremor detection capability and used as inputs in a multi-feature neural network classifier to identify the activity of Parkinsonian tremor. The results of this study show that a trained multi-feature neural network is able, under certain conditions, to achieve excellent detection accuracy on patients unseen during training. Overall the tremor detection accuracy was mixed, although an accuracy of over 86% was achieved in four out of the eight patients.

[1]  Kevin Warwick,et al.  Identifying tremor-related characteristics of basal ganglia nuclei during movement in the Parkinsonian patient. , 2010, Parkinsonism & related disorders.

[2]  Tipu Z. Aziz,et al.  Parkinson's Disease tremor classification - A comparison between Support Vector Machines and neural networks , 2012, Expert Syst. Appl..

[3]  Nicola J. Ray,et al.  The role of the subthalamic nucleus in response inhibition: Evidence from deep brain stimulation for Parkinson's disease , 2009, Neuropsychologia.

[4]  H. Schwarzlander,et al.  Demodulation Procedure for Very Wide-Band FM , 1977, IEEE Trans. Commun..

[5]  Andrea A. Kühn,et al.  The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease , 2005, Experimental Neurology.

[6]  J. Dostrovsky,et al.  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. , 2006, Journal of neurophysiology.

[7]  Andrea A. Kühn,et al.  Frequency-dependent distribution of local field potential activity within the subthalamic nucleus in Parkinson's disease , 2007, Experimental Neurology.

[8]  Tipu Z. Aziz,et al.  Prediction of Parkinson's Disease tremor Onset Using a Radial Basis Function Neural Network Based on Particle Swarm Optimization , 2010, Int. J. Neural Syst..

[9]  Hagai Bergman,et al.  Delimiting subterritories of the human subthalamic nucleus by means of microelectrode recordings and a Hidden Markov Model , 2009, Movement disorders : official journal of the Movement Disorder Society.

[10]  Elif Derya íbeyli Statistics over features: EEG signals analysis , 2009 .

[11]  Elif Derya Ubeyli,et al.  Statistics over features: EEG signals analysis. , 2009, Computers in biology and medicine.

[12]  M. Brin,et al.  Consensus Statement of the Movement Disorder Society on Tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[13]  Marc Timme,et al.  Phase synchronization between LFP and spiking activity in motor cortex during movement preparation , 2007, Neurocomputing.

[14]  Elif Derya Übeyli Time-varying biomedical signals analysis with multiclass support vector machines employing Lyapunov exponents , 2007, Digit. Signal Process..

[15]  B. Schibye,et al.  Short latency stretch reflex in human lumbar paraspinal muscles , 2005, Journal of Neuroscience Methods.

[16]  Kurt Hornik,et al.  Multilayer feedforward networks are universal approximators , 1989, Neural Networks.

[17]  A. E. Lang,et al.  Identification and characterization of neurons with tremor-frequency activity in human globus pallidus , 1997, Experimental Brain Research.

[18]  J. Dostrovsky,et al.  Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity , 2002, The Journal of Neuroscience.

[19]  I. E. Holliday,et al.  Abnormal thalamocortical dynamics may be altered by deep brain stimulation: Using magnetoencephalography to study phantom limb pain , 2009, Journal of Clinical Neuroscience.

[20]  P. Ashby,et al.  Coherence between cerebellar thalamus, cortex and muscle in man: cerebellar thalamus interactions. , 2000, Brain : a journal of neurology.

[21]  Andrea A. Kühn,et al.  High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance , 2008, The Journal of Neuroscience.

[22]  K. Newell,et al.  Differential time- and frequency-dependent structure of postural sway and finger tremor in Parkinson's disease , 2008, Neuroscience Letters.

[23]  Carlos M. Magariños‐Ascone,et al.  Subthalamic neuron activity related to tremor and movement in Parkinson's disease , 2000, The European journal of neuroscience.

[24]  Bin Hu,et al.  High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal–striatal theta coherence following haloperidol-induced catalepsy , 2008, Experimental Neurology.

[25]  Po-Lei Lee,et al.  Frequency recognition in an SSVEP-based brain computer interface using empirical mode decomposition and refined generalized zero-crossing , 2011, Journal of Neuroscience Methods.

[26]  P. Brown Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.

[27]  H. Bergman,et al.  Basal ganglia oscillations and pathophysiology of movement disorders , 2006, Current Opinion in Neurobiology.

[28]  M. Baker,et al.  The journey: Parkinson's disease , 2004, BMJ : British Medical Journal.

[29]  K. Mewes,et al.  The Subthalamic Nucleus and Tremor in Parkinson's Disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[30]  H. Bergman,et al.  Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony. , 2008, Brain : a journal of neurology.

[31]  M A B BRAZIER,et al.  Cross-correlation and autocorrelation studies of electroencephalographic potentials. , 1952, Electroencephalography and clinical neurophysiology.

[32]  P. Brown,et al.  Online prediction of self-paced hand-movements from subthalamic activity using neural networks in Parkinson’s disease , 2004, Journal of Neuroscience Methods.

[33]  J. Stein,et al.  The oscillatory activity in the Parkinsonian subthalamic nucleus investigated using the macro-electrodes for deep brain stimulation , 2002, Clinical Neurophysiology.

[34]  Necmettin Sezgin,et al.  A new approach for estimation of obstructive sleep apnea syndrome , 2011, Expert Syst. Appl..

[35]  M. Akay,et al.  Biosignal pattern recognition and interpretation systems , 1993, IEEE Engineering in Medicine and Biology Magazine.

[36]  Tipu Z. Aziz,et al.  Revealing the dynamic causal interdependence between neural and muscular signals in Parkinsonian tremor , 2007, J. Frankl. Inst..

[37]  M. Akay,et al.  Biosignal pattern recognition and interpretation systems. 4. Review of applications , 1994, IEEE Engineering in Medicine and Biology Magazine.

[38]  J. Carr Tremor in Parkinson's disease. , 2002, Parkinsonism & related disorders.

[39]  Tadashi Masuda,et al.  The Measurement of Muscle Fiber Conduction Velocity Using a Gradient Threshold Zero-Crossing Method , 1982, IEEE Transactions on Biomedical Engineering.

[40]  H. Bergman,et al.  Pathological synchronization in Parkinson's disease: networks, models and treatments , 2007, Trends in Neurosciences.

[41]  J. Timmer,et al.  Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients , 2008, Neuroscience Letters.

[42]  Yun Peng,et al.  A connectionist approach to diagnostic problem solving using causal networks , 1993, Inf. Sci..

[43]  Tipu Z. Aziz,et al.  Time–frequency analysis of transient neuromuscular events: dynamic changes in activity of the subthalamic nucleus and forearm muscles related to the intermittent resting tremor , 2005, Journal of Neuroscience Methods.

[44]  M. Fiorio,et al.  Modulation of beta oscillations in the subthalamic area during action observation in Parkinson's disease , 2009, Neuroscience.

[45]  G. Deuschl,et al.  Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state. , 2008, Journal of neurophysiology.

[46]  Hagai Bergman,et al.  Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease. , 2010, Brain : a journal of neurology.

[47]  A. Rajput Epidemiology of Parkinson’s Disease , 1984, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[48]  P Limousin-Dowsey,et al.  Subthalamic nucleus, sensorimotor cortex and muscle interrelationships in Parkinson's disease. , 2001, Brain : a journal of neurology.

[49]  F. A. Lenz,et al.  Tremor-frequency (3–6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease , 1999, Neuroscience Letters.