A. Coutinho

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A. Coutinho, Antonio Coutinho, 1989, Immunological reviews.

F. Varela, A. Coutinho, Antonio Coutinho, 1991, Immunology today.

Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice.

A. Coutinho, S. Avrameas, D. Holmberg, 1986, Annales de l'Institut Pasteur. Immunology.

The relationship between connectivity and tolerance as revealed by computer simulation of the immune network: some lessons for an understanding of autoimmunity.

F. Varela, A. Coutinho, J. Stewart, 1989, Journal of autoimmunity.

Evidence for a functional idiotypic network among natural antibodies in normal mice.

F. Varela, A. Coutinho, I. Lundkvist, 1989, Proceedings of the National Academy of Sciences of the United States of America.

A model of the immune network with B-T cell co-operation. I--Prototypical structures and dynamics.

A. Coutinho, J. Stewart, J. Carneiro, 1996, Journal of theoretical biology.

A model of the immune network with B-T cell co-operation. II--The simulation of ontogenesis.

A. Coutinho, J. Stewart, J. Carneiro, 1996, Journal of theoretical biology.

Autonomous activation of B and T cells in antigen‐free mice

A. Coutinho, M. Cooper, C. Heusser, 1986, European journal of immunology.

Metabolic adaptation to tissue iron overload confers tolerance to malaria.

L. Kühn, A. Coutinho, B. Andrade, 2012, Cell host & microbe.

Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment.

A. Coutinho, A. Freitas, M. Lembezat, 1989, International immunology.

Thymic epithelium tolerizes for histocompatibility antigens.

A. Coutinho, J. Salaün, A. Bandeira, 1990, Science.

Clonal persistence of B lymphocytes in normal mice is determined by variable region‐dependent selection

A. Coutinho, A. Freitas, V. Thomas-Vaslin, 1991, European journal of immunology.

Transplantation tolerance is unrelated to superantigen-dependent deletion and anergy.

A. Coutinho, O. Burlen-defranoux, J. Salaün, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Global analysis of antibody repertoires. II. Evidence for specificity, self‐selection and the immunological “homunculus” of antibodies in normal serum

A. Coutinho, M. Haury, A. Grandien, 1993, European journal of immunology.

Serum IgM repertoire reactions to MBP/CFA immunization reflect the individual status of EAE susceptibility.

A. Coutinho, C. Fesel, 2000, Journal of autoimmunity.

Life span of B lymphocytes: the experimental basis for conflicting results.

A. Coutinho, B. Rocha, A. Freitas, 1986, Journal of immunology.

Self-reactive antibodies (natural autoantibodies) in healthy individuals.

A. Coutinho, S. Kaveri, S. Lacroix-Desmazes, 1998, Journal of immunological methods.

From an Antigen‐Centered, Clonal Perspective of Immune Responses to an Organism‐Centered, Network Perspective of Autonomous Activity in a Self‐Referential Immune System

A. Coutinho, D. Holmberg, L. Forni, 1984, Immunological reviews.

The ontogeny of class-regulation of CD4+ T lymphocyte populations.

A. Coutinho, J. Carneiro, J Carneiro, 1995, International immunology.

Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

A. Coutinho, J. Andersson, F. Melchers, 1977, Cell.

Two distinct factors are required for induction of T-cell growth

A. Coutinho, E. Larsson, N. Iscove, 1980, Nature.

Establishment of idiotypic helper T-cell repertoires early in life

P. Pereira, A. Coutinho, C. Martínez-A, 1985, Nature.

Maternal transmission of idiotypic network interactions selecting available T cell repertoires

A. Coutinho, M. Toribio, C. Martínez-A, 1986, European journal of immunology.

Primary Immunodeficiencies Unravel Critical Aspects of the Pathophysiology of Autoimmunity and of the Genetics of Autoimmune Disease

A. Coutinho, M. Carneiro-Sampaio, 2008, Journal of Clinical Immunology.

B cell activities in normal unmanipulated mice.

P. Pereira, A. Coutinho, A. Freitas, 1989, Contributions to microbiology and immunology.

Lymphocyte Population Kinetics in the Mouse

A. Coutinho, B. Rocha, A. Freitas, 1986, Immunological reviews.

Thymic epithelium induces full tolerance to skin and heart but not to B lymphocyte grafts

A. Coutinho, J. Salaün, A. Bandeira, 1995, European journal of immunology.

Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell pools

A. Coutinho, O. Burlen-defranoux, A. Bandeira, 1994, European journal of immunology.

Expression and selection of murine antibody repertoires.

A. Coutinho, D. Holmberg, A. Grandien, 1992, International reviews of immunology.

Normal serum immunoglobulins influence the numbers of bone marrow pre‐B and B cells

A. Coutinho, C. Heusser, A. Freitas, 1991, European journal of immunology.

Selection of anti-F protein B-cell repertoires in normal mice.

A. Coutinho, N. Nardi, A. Freitas, 1990, Research in immunology.

Immunobiology of Murine T Cruzi Infection: The Predominance of Parasite‐nonspecific Responses and the Activation of TCRIT Cells

S. Tonegawa, S. Itohara, A. Coutinho, 1989, Immunological reviews.

Idiotype-specific regulation might contribute to specific unresponsiveness in dextran-primed mice.

A. Coutinho, I. Lundkvist, D. Portnoi, 1989, Research in immunology.

Idiotypes, tailors and networks.

A. Coutinho, A. Grandien, J. Faro-Rivas, 1988, Annales de l'Institut Pasteur. Immunology.

A phenotypic and functional analysis of long-lived B and T lymphocytes.

A. Coutinho, L. Forni, A. Bandeira, 1988, Cellular immunology.

Frequencies of mitogen-reactive B cells in the mouse. I. Distribution in different lymphoid organs from different inbred strains of mice at different ages

A. Coutinho, F. Melchers, J. Andersson, 1977, The Journal of experimental medicine.

Two major classes of mitogen-reactive B lymphocytes defined by life span.

A. Coutinho, B. Rocha, A. Freitas, 1986, Journal of immunology.

Analysis of natural and disease-associated autoantibody repertoires: anti-endothelial cell IgG autoantibody activity in the serum of healthy individuals and patients with systemic lupus erythematosus.

A. Coutinho, M. Haury, S. Kaveri, 1994, International immunology.

The Age‐Associated Increase in Autoreactive Immunoglobulins Reflects a Quantitative Increase in Specificities Detectable at Lower Concentrations in Young Mice

A. Coutinho, M. Haury, M. Weksler, 1996, Scandinavian journal of immunology.

Characteristic generated alterations of autoantibody patterns in idiopathic thrombocytopenic purpura.

A. Coutinho, M. Haury, A. Nobrega, 1997, Journal of Autoimmunity.

Genetic control of natural antibody repertoires: I. IgH, MHC and TCRβ loci

A. Coutinho, M. Haury, A. Nobrega, 1998, European Journal of Immunology.

Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells

A. Coutinho, C. Corbel, A. Bandeira, 1996, Immunological reviews.

Neonatal Tolerance to Alloantigens is Induced by Enriched Antigen‐Presenting Cells

A. Coutinho, A. Bandeira, Y. Modigliani, 1997, Scandinavian journal of immunology.

Differential requirements for activation and growth of unprimed cytotoxic and helper T lymphocytes

A. Coutinho, M. Gullberg, E. Larsson, 1983, European journal of immunology.

Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires.

A. Coutinho, C. Heusser, A. Freitas, 1991, Proceedings of the National Academy of Sciences of the United States of America.

In vivo models of dominant T-cell tolerance: where do we stand today?

A. Coutinho, W. Haas, 2001, Trends in immunology.

Naturally activated CD4+ T cells are highly enriched for cytokine‐producing cells

A. Coutinho, F. Ivars, A. Bandeira, 1998, European journal of immunology.

Thymic epithelium induces neither clonal deletion nor anergy to Mls 1a antigens

A. Coutinho, A. Bandeira, I. Khazaal, 1992, European journal of immunology.

B lymphocyte activation upon exclusive recognition of major histocompatibility antigens by T helper cells

A. Coutinho, C. Martínez-A, S. Pettersson, 1984, European journal of immunology.

Differential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation

A. Coutinho, A. Bandeira, S. Petterson, 1983, The Journal of experimental medicine.

Macrophages Suppress Direct B‐Cell Activation by Lipopolysaccharide

A. Coutinho, H. Lemke, H. Opitz, 1975, Scandinavian journal of immunology.

Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium

P. Pereira, A. Coutinho, A. Bandeira, 1996, European journal of immunology.

Localization of 7/6 T Cells to the Intestinal Epithelium Is Independent of Normal Microbial Colonization

A. Coutinho, C. Heusser, Sylvie, 1990 .

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice.

A. Coutinho, D. Damotte, M. Coltey, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Peripheral expansion of thymus‐derived regulatory cells in anti‐myelin basic protein T cell receptor transgenic mice

A. Coutinho, M. Haury, J. Demengeot, 2002, European journal of immunology.

Regulatory T cells in thymic epithelium‐induced tolerance. I. Suppression of mature peripheral non‐tolerant T cells

P. Pereira, A. Coutinho, A. Bandeira, 1995, European journal of immunology.

Fetal-onset IPEX: report of two families and review of literature.

A. Coutinho, C. Moreira-Filho, M. Carneiro-Sampaio, 2015, Clinical immunology.

MECHANISM OF THYMUS-INDEPENDENT IMMUNOCYTE TRIGGERING

A. Coutinho, G. Möller, W. W. Bullock, 1974, The Journal of experimental medicine.

A novel cell surface molecule on early B-lineage cells

A. Coutinho, M. Cooper, P. Cazenave, 1986, Nature.

A plaque assay for all cells secreting Ig of a given type or class

A. Coutinho, F. Melchers, E. Gronowicz, 1976, European journal of immunology.

Old dogs and new tricks: Defective peripheral regulatory T cell generation in aged mice

A. Coutinho, Thiago Lopes-Carvalho, 2013, European journal of immunology.

I-E-linked control of spontaneous rheumatoid factor production in normal mice

P. Pereira, A. Coutinho, Pablo Pereira, 1989, The Journal of experimental medicine.

Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides

A. Coutinho, G. Moller, E. Gronowicz, 1975, The Journal of experimental medicine.

Murine Acariasis. II. Immunological Dysfunction and Evidence for Chronic Activation of Th‐2 Lymphocytes

A. Coutinho, P. Minoprio, A. Freitas, 1996, Scandinavian journal of immunology.

Polyclonal Lymphocyte Responses to Murine Trypanosoma cruzi Infection

A. Coutinho, P. Minoprio, H. Eisen, 1986, Scandinavian journal of immunology.

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

S. Tonegawa, S. Itohara, A. Coutinho, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Studies on T lymphocyte activation II. The target cells for concanavalin A‐induced growth factors

A. Coutinho, E. Larsson, J. Andersson, 1979, European journal of immunology.

Immunity to Microbes: Lessons from Primary Immunodeficiencies

A. Coutinho, M. Carneiro-Sampaio, 2007, Infection and Immunity.

Molecular Basis of B‐Cell Activation

A. Coutinho, G. Möller, W. Richter, 1974, Scandinavian journal of immunology.

B lymphocyte sensitivity to IgM receptor ligation is independent of maturation stage and locally determined by macrophage-derived IFN-beta.

A. Coutinho, J. Demengeot, A. Grandien, 1997, International immunology.

Inside the thymus, Mls antigen is exclusively presented by B lymphocytes.

A. Coutinho, J. Faro, C. Martínez-A, 1990, Research in immunology.

Further evidence for coelomic‐associated b lymphocytes

P. Pereira, A. Coutinho, C. Martínez-A, 1989, European journal of immunology.

Xid-associated resistance to experimental Chagas' disease is IFN-gamma dependent.

R. Coffman, A. Coutinho, A. O’Garra, 1993, Journal of immunology.

Intrauterine IPEX

A. Coutinho, J. Demengeot, C. Moreira-Filho, 2020, Frontiers in Pediatrics.

The role of I-A/E molecules in B lymphocyte activation. I. Inhibition of lipopolysaccharide-induced responses by monoclonal antibodies.

A. Coutinho, M. Pierres, G. Pobor, 1984, Journal of immunology.

IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei–Infected Mice

A. Coutinho, C. Penha-Gonçalves, M. Martins, 2013, The Journal of Immunology.

Targeted disruption of the VH 81X gene: Influence on the B cell repertoire

K. Rajewsky, J. Roes, A. Coutinho, 1997, European journal of immunology.

Genetic and functional characterization of an antiserum to the lipid A‐specific triggering receptor on murine B lymphocytes

A. Coutinho, L. Forni, T. Watanabe, 1978, European journal of immunology.

An antiserum which recognizes lipopolysaccharidereactive B cells in the mouse

A. Coutinho, L. Forni, 1978, European journal of immunology.

Requirement for the Involvement of Clonally Distributed Receptors in the Activation of Cytotoxic T Lymphocytes

A. Coutinho, M. Gullberg, E. Larsson, 1982, Immunological reviews.

Role of C'3 and Fc receptors in B-lymphocyte activation

A. Coutinho, G. Möller, 1975, Journal of Experimental Medicine.

Mechanism of B‐Lymphocyte Activation: Failure to Obtain Evidence of a Direct Role of the Ig Receptors in the Triggering Process

A. Coutinho, U. Persson, G. Möller, 1975, Scandinavian journal of immunology.

SIGNALS AND RECEPTORS IN B CELL ACTIVATION

A. Coutinho, G. Möller, E. Gronowicz, 1975 .

The role of mitogenic lectins in T-cell triggering

A. Coutinho, E. Larsson, 1979, Nature.

Immunoglobulin C‐gene expression. I. The commitment to IgG subclass of secretory cells is determined by the quality of the nonspecific stimuli

A. Coutinho, A. Augustin, C. Martínez-Alonso, 1980, European journal of immunology.

Independent Segregation of Two Functional Markers Expressed on the Same B‐Cell Subset in the Mouse: The Mls Determinants and LPS Receptors

A. Coutinho, T. Meo, T. Watanabe, 1977, Scandinavian journal of immunology.

A common idiotope on T cell receptors and antibodies expressed in the absence of network selection

P. Pereira, A. Coutinho, C. Martínez-A, 1987, European journal of immunology.

The basis for major histocompatibility complex (MHC) and immunoglobulin gene control of helper T cell idiotopes

P. Pereira, A. Coutinho, C. Martínez-A, 1986, European journal of immunology.

Ontogenic development of B cell reactivities to cooperative cell signals: Dissociation between proliferation and antibody secretion

A. Coutinho, S. Pettersson, G. Pobor, 1982, European journal of immunology.

A. Coutinho, C. Martínez-A, E. Larsson, 1980, Immunological reviews.

The interaction between DC and Plasmodium berghei/chabaudi‐infected erythrocytes in mice involves direct cell‐to‐cell contact, internalization and TLR

A. Coutinho, E. Seixas, J. M. Moura Nunes, 2009, European journal of immunology.

StimulationCell Responsiveness to Lipopolysaccharide MHC Class II Molecules Control Murine B

A. Coutinho, J. Demengeot, L. Gonçalves, 2006 .

Hapten‐induced B cell paralysis. II. Evidence for trivial mechanisms of tolerance

A. Coutinho, E. Gronowicz, 1975, European journal of immunology.

Activation of Lyt‐2+ T cells by antibodies towards brain‐associated antigens: II. Antibody‐dependent induction of “nonspecific” cell‐mediated cytotoxicity

A. Coutinho, M. Gullberg, 1985, European journal of immunology.

Back‐stimulation of B lymphocytes binding to helper T cell surface antigens

P. Pereira, A. Coutinho, M. Toribio, 1988, European journal of immunology.

Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.

A. Coutinho, J. Frelinger, J. Niederhuber, 1975, Journal of immunology.

Purification and characterization of intraparenchymal lung lymphocytes.

A. Coutinho, E. Abraham, A. Freitas, 1990, Journal of immunology.

All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes.

A. Coutinho, P. Cazenave, H. Masmoudi, 1990, International immunology.

Clonal analysis of the specificity of alloreactive cells: “Dominance” of Eβ reactive clones

A. Coutinho, S. Pettersson, G. Pobor, 2004, Immunogenetics.

Studies on T lymphocyte activation I. Requirements for the mitogen‐dependent production of T cell growth factors

A. Coutinho, E. Larsson, Jan Andersson, 1979, European journal of immunology.

The Vβ8 Gene Family is Preferentially Used by‘Naturally’Activated T Cells

A. Coutinho, L. Forni, Antonio Coutinho, 1988 .

Functional double‐negative T cells in the periphery express T cell receptor Vβ gene products that cause deletion of single‐positive T cells

A. Coutinho, G. Kroemer, C. Martínez-A, 1993, European journal of immunology.

Suppression of polyclonal antibody production in Trypanosoma cruzi-infected mice by treatment with anti-L3T4 antibodies.

P. Pereira, A. Coutinho, P. Minoprio, 1987, Journal of immunology.

A Remarkable Depletion of Both Naïve CD4+ and CD8+ with High Proportion of Memory T Cells in an IPEX Infant with a FOXP3 Mutation in the Forkhead Domain

A. Coutinho, A. Vicente, M. Carneiro-Sampaio, 2008, Scandinavian journal of immunology.

Questions on the Emergence of T-cell Repertoires

P. Pereira, A. Coutinho, C. Martínez-A, 2020 .

Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity.

A. Coutinho, D. Holmberg, G. Dighiero, 1989, Research in immunology.

MHC restriction of male-antigen-specific T helper cells collaborating in antibody responses

A. Coutinho, S. Pettersson, G. Pobor, 2004, Immunogenetics.

Characterization of Dextran‐Sulfate‐Sensitive Cells

A. Coutinho, P. Biberfeld, B. Wahrén, 1976, Scandinavian journal of immunology.

B-lineage cell deficits in bone marrow of lpr/lpr mice.

A. Coutinho, A. Sundblad, 1996, International immunology.

Regulation of VH‐gene expression is a lineage‐specific developmental marker

A. Coutinho, A. Freitas, A. Viale, 1994, European journal of immunology.

Immunoglobulin VH gene expression in Ly‐1+ and conventional B lymphocytes

A. Coutinho, A. Freitas, P. Poncet, 1989, European journal of immunology.

Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells.

A. Coutinho, M. Russo, N. Starobinas, 1988, Annales de l'Institut Pasteur. Immunology.

Functional Recognition of Bacterial Mitogens by Reactive B Lymphocytes Related to Membrane Protein Composition

A. Coutinho, W. Bessler, H. Vordermeier, 1987 .

Developmental shift in the patterns of interleukin production in early post‐natal life

A. Coutinho, A. Bandeira, G. Coutinho, 1994, European journal of immunology.

Interactions of small B lymphocytes with unprimed noncytolytic T cells: dissociation between “presentation” and growth induction

P. Pereira, A. Coutinho, C. Martínez-A, 1985, European journal of immunology.

Polyclonal Lymphocyte Responses to Murine Trypanosoma cruzi Infection

A. Coutinho, P. Minoprio, H. Eisen, 1986, Scandinavian journal of immunology.

Differential Binding of Natural Monoclonal Antibodies to the Surface of Fixed or Living Cells

A. Coutinho, M. Ermonval, C. Rossi, 1989, Scandinavian journal of immunology.

Heterogeneity of B Cells: Direct Evidence of Selective Triggering of Distinct Subpopulations by Polyclonal Activators

A. Coutinho, E. Gronowicz, 1976, Scandinavian Journal of Immunology.

Clonal Growth of T Cells in vitro: Preliminary Attempts to a Quantitative Approach

A. Coutinho, C. Fathman, T. Watanabe, 1977, Immunological reviews.

Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function

A. Coutinho, A. Augustin, 1980, The Journal of experimental medicine.

An outsider's view on SLE research

A. Coutinho, 1999, Lupus.

Endogenous VH gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires.

A. Coutinho, A. Grandien, A. Freitas, 1991, International immunology.

The Immune Response to Bacterial Dextrans

A. Coutinho, D. Holmberg, F. Ivars, 1983, Scandinavian journal of immunology.

IgM‐Induced Specific Antibody Responses: Direct Correlation between Responsiveness and Natural or Induced Recurrence of the Idiotype

A. Coutinho, D. Holmberg, P. Cazenave, 1983, Scandinavian journal of immunology.

Selective peripheral expansion and activation of B cells expressing endogenous immunoglobulin in μ‐transgenic mice

A. Coutinho, A. Grandien, J. Andersson, 1990, European journal of immunology.

Sporadic idiotypic cross-reactivities between antibodies and T helper cells: one example of aleatory expression of T cell idiotypes.

P. Pereira, A. Coutinho, M. Toribio, 1987, The Journal of molecular and cellular immunology : JMCI.

Divergency in the specificity of the induction and maintenance of neonatal suppression

A. Coutinho, P. Cazenave, A. Freitas, 1990, European journal of immunology.

The role of immunoglobulin receptors in “cognate” T‐B cell collaboration

P. Pereira, A. Coutinho, C. Martínez-A, 1986, European journal of immunology.

The Role of I‐A/E Molecules in B‐Lymphoeyte Activation

A. Coutinho, C. Martínez-A, S. Forsgren, 1987 .

On the role of I‐A antigens in lectin‐ and antigen‐induced interleukin 2 production

A. Coutinho, E. Larsson, 1984, European journal of immunology.

No histocompatibility requirements for macrophage-lymphocyte interactions in the primary immune antibody response to sheep erythrocytes in vitro

A. Coutinho, H. Lemke, G. Möller, 1976 .

Mitogen-activated B-cell blasts reactive to more than one mitogen

A. Coutinho, F. Melchers, J. Andersson, 1979, The Journal of experimental medicine.

Pre-/post-otic rhombomeric interactions control the emergence of a fetal-like respiratory rhythm in the mouse embryo.

A. Coutinho, J. Champagnat, G. Fortin, 2006, Journal of neurobiology.

Physiopathology of natural auto-antibodies: the case for regulation.

A. Coutinho, S. Zelenay, J. Demengeot, 2007, Journal of autoimmunity.

Decreased AIRE Expression and Global Thymic Hypofunction in Down Syndrome

P. L. Ramos, A. Coutinho, H. Brentani, 2011, The Journal of Immunology.

Functional Analysis of B Cell Heterogeneity

A. Coutinho, Antonio Coutinho, Eva Ronowicz, 1975, Transplantation reviews.

Murine acariasis: I. Pathological and clinical evidence suggesting cutaneous allergy and wasting syndrome in BALB/c mouse.

A. Coutinho, J. Guénet, P. Cazenave, 1996, Research in immunology.

Complement and antibody primary immunodeficiency in juvenile systemic lupus erythematosus patients

A. Coutinho, C. Silva, S. Bando, 2011, Lupus.

The repertoire of serum IgM in normal mice is largely independent of external antigenic contact

A. Coutinho, M. Haury, A. Grandien, 1997, European journal of immunology.

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization

S. Tonegawa, S. Itohara, A. Coutinho, 1990, The Journal of experimental medicine.

Thymus-independent B-cell induction and paralysis.

A. Coutinho, G. Möller, Göran Möller, 1975, Advances in immunology.

Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.

A. Coutinho, I. Caramalho, J. Demengeot, 2005, Current topics in microbiology and immunology.

Positive and Negative Selection of Antibody Repertoires during B‐Cell Differentiation

A. Coutinho, A. Grandien, A. Freitas, 1994, Immunological reviews.

Administration to mouse of endotoxin from gram‐negative bacteria leads to activation and apoptosis of T lymphocytes

A. Coutinho, P. Truffa-bachi, V. Bemer, 1998, European journal of immunology.

A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase

A. Coutinho, W. Degrave, B. Reina-San-Martin, 2000, Nature Medicine.

Hapten‐specific helper T cells III. Fine specificity of the (4‐hydroxy‐3‐nitro‐phenyl)‐acetyl (NP)‐specific response in Igh‐1b mice

A. Coutinho, R. Bernabé, H. von Boehmer, 1981, European journal of immunology.

Immunoglobulin C‐gene expression. III. Possible induction of specific genetic events in activated B lymphocytes by the polyclonal stimuli driving clonal expansion

A. Coutinho, C. Martínez-Alonso, Carlos Martinez‐Alonso, 1982, European journal of immunology.

Hapten‐specific helper T cells. II. Genetic determination of functional recognition

A. Coutinho, R. Bernabé, H. Pohlit, 1980 .

Hapten‐specific helper T cells. I. Collaboration with B cells to which the hapten has been directly coupled

A. Coutinho, R. Bernabé, H. Pohlit, 1980 .

The specificity of nonspecific concanavalin A‐induced helper factors

A. Coutinho, C. Martínez-Alonso, Rosa R. Bemabé, 1979, European journal of immunology.

The immune response to bacterial dextrans. V. A "dominant" idiotype in IgCHb mice.

A. Coutinho, I. Lundkvist, D. Holmberg, 1987, Journal of immunology.

Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

A. Coutinho, S. Avrameas, D. Holmberg, 1986, Immunological reviews.

The immune response to bacterial dextrans III. Ontogenic development and strain distribution of specific clonal precursors

A. Coutinho, I. Lundkvist, D. Holmberg, 1986, European journal of immunology.

High frequency of natural autoantibodies in normal newborn mice.

A. Coutinho, S. Avrameas, D. Holmberg, 1985, Journal of immunology.

Mechanism of B‐Cell Activation and Paralysis by Thymus‐Independent Antigens

A. Coutinho, G. Möller, E. Gronowicz, 1975, Scandinavian journal of immunology.

Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

A. Coutinho, T. Meo, 1978, Immunogenetics.

In vitro activation of mouse lymphocytes in serum‐free medium: effect of T and B cell mitogens on proliferation and antibody synthesis

A. Coutinho, G. Möller, J. Andersson, 1973, European journal of immunology.

Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes

A. Coutinho, N. L. Le Douarin, J. Salaün, 2002, Proceedings of the National Academy of Sciences of the United States of America.

VH‐Gene Family Dominance in Ageing Mice

A. Coutinho, A. Freitas, M. Weksler, 1994, Scandinavian journal of immunology.

Receptor interactions on the membrane of resting and activated B cells

A. Coutinho, L. Forni, 1978, Nature.

Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes, and trinitrophenylated or nitrodophenylated sheep erythrocytes

A. Coutinho, F. Melchers, A Coutinho, 1977, The Journal of experimental medicine.

Idiotypic Multireactivity of ‘Natural’ Antibodies

A. Coutinho, C. Martínez-A, D. Holmberg, 1987, Scandinavian journal of immunology.

Cloning of murine transformed cell lines in suspension culture with efficiencies near 100%.

A. Coutinho, F. Melchers, W. Lernhardt, 1978, Experimental cell research.

Quantitative studies on concanavalin A-induced, TCGF-reactive T cells. I. Correlation between proliferation and lectin-dependent cytolytic activity.

A. Coutinho, J. Langhorne, K. F. Lindahl, 1981, Journal of immunology.

T Cell‐Dependent B Cell Activation

P. Pereira, A. Coutinho, C. Martínez-A, 1984, Immunological reviews.

Continuous Growth of Mitogen‐Reactive B Lymphocytes

A. Coutinho, F. Melchers, G. Heinrich, 1975 .

Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

T. Clark, A. Coutinho, O. Wagner, 2010, PloS one.

Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes.

P. Pereira, A. Coutinho, R. Bernabé, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Innate immunity: from lymphocyte mitogens to Toll-like receptors and back.

A. Coutinho, A. Poltorack, 2003, Current opinion in immunology.

TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells

A. Coutinho, M. Bellio, F. Montalvão, 2018, Front. Immunol..

Genetic Control of B‐Cell Responses

A. Coutinho, 1976, Scandinavian journal of immunology.

Inhibition of In Vitro Immune Responses by a Fraction from Seminal Plasma

A. Coutinho, G. Möller, C. Prakash, 1976, Scandinavian journal of immunology.

Cellular basis for the age-associated increase in autoimmune reactions.

A. Coutinho, M. Weksler, F. Huetz, 1990, International immunology.

Segregation of reactivity to the mitogens lipopolysaccharide, lipoprotein and dextran sulfate in clones of the B cell lymphoma line WEHI 279.1

A. Coutinho, Bernhard Kleine, Wolfgang Bessler, 1985, European journal of immunology.

Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

A. Coutinho, F. Melchers, L. Forni, 1977, European journal of immunology.

Genetic Control of B‐Cell Responses

A. Coutinho, B. M. Sultzer, E. Gronowicz, 1975, Scandinavian journal of immunology.

Selective triggering of B cell subpopulations by mitogens

A. Coutinho, E. Gronowicz, 1974, European journal of immunology.

The majority of “natural” immunoglobulin‐secreting cells are short‐lived and the progeny of cycling lymphocytes

A. Coutinho, P. Vieira, A. Freitas, 1987, European journal of immunology.

9 – The Protein A Plaque Assay for the Detection of Immunoglobulin-Secreting Cells

A. Coutinho, C. Martínez-A, D. Holmberg, 1981 .

Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen

A. Coutinho, L. Forni, B. Blomberg, 1978, The Journal of experimental medicine.

Genetical control of B-cell responses. III. Requirement for functional mitogenicity of the antigen in thymus-independent specific responses

A. Coutinho, E. Gronowicz, 1975, The Journal of experimental medicine.

Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease.

A. Coutinho, I. Caramalho, S. Zelenay, 2009, Journal of autoimmunity.

Mitogenic properties of the thymus‐independent antigen pneumococcal polysaccharide siii

A. Coutinho, G. Möller, 1973, European journal of immunology.

Analysis of the natural human IgG antibody repertoire: life‐long stability of reactivities towards self antigens contrasts with age‐dependent diversification of reactivities against bacterial antigens

A. Coutinho, S. Lacroix-Desmazes, M. Kazatchkine, 1995, European journal of immunology.

Biased VH gene expression in murine CD5 B cells results from age‐dependent cellular selection

A. Coutinho, P. Poncet, V. Thomas-Vaslin, 1991, European journal of immunology.

A “Trans” Perspective on the Control of Immunoglobulin C Gene Expression

A. Coutinho, C. Martínez-A, D. Holmberg, 1982, Immunological reviews.

The production of membrane or secretory forms of immunoglobulins is regulated by C-gene-specific signals

A. Coutinho, L. Forni, 1982, Nature.

Stimulation of B and T cells by in vivo high dose immunoglobulin administration in normal mice.

A. Coutinho, A. Sundblad, F. Huetz, 1991, Journal of autoimmunity.

The Physiology of Autoimmune Reactivities

A. Coutinho, S. Avrameas, A. Grandien, 1989 .

B cell mitogenic properties of thymus-independent antigens.

A. Coutinho, G. Möller, Göran Möller, 1973, Nature: New biology.

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

A. Coutinho, M. Soares, Ana Ferreira, 2009, Proceedings of the National Academy of Sciences.

Derivation of hybrids between a thymoma line and spleen cells activated in a mixed leukocyte reaction

A. Coutinho, B. Elliott, G. Köhler, 1977, European journal of immunology.

Increased IgE serum levels are unrelated to allergic and parasitic diseases in patients with juvenile systemic lupus erythematosus

A. Coutinho, C. Silva, M. Carneiro-Sampaio, 2012, Clinics.

Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development.

A. Coutinho, A. Freitas, M. Lembezat, 1990, International immunology.

Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs.

A. Coutinho, B. Rocha, A. Freitas, 1982, Journal of immunology.

Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen

A. Coutinho, L. Hammarström, U. Persson, 1976, The Journal of experimental medicine.

Will the idiotypic network help to solve natural tolerance?

A. Coutinho, António Coutinho, 2003, Trends in immunology.

Functional diversity and clonal frequencies of reactivity in the available antibody repertoire

A. Coutinho, M. Haury, A. Grandien, 1998, European journal of immunology.

Positive selection of γδ T cells

S. Tonegawa, A. Coutinho, J. Lafaille, 1990 .

The physiology of bcl-2 expression in murine B lymphocytes.

A. Coutinho, M. Haury, A. Freitas, 1993, Oncogene.

Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: Studies in M54 μ‐transgenic mice

A. Coutinho, A. Grandien, M. Weksler, 1993, European journal of immunology.

Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice

A. Coutinho, A. Freitas, A. Viale, 1992, The Journal of experimental medicine.

Activation of Helper T Cells for B Lymphocytes in Primary Mixed Lymphocyte Cultures

A. Coutinho, C. Martínez-A, S. Pettersson, 1983, Scandinavian journal of immunology.

B cell participation in the recursive selection of T cell repertoires

P. Pereira, A. Coutinho, C. Martínez-A, 1988, European journal of immunology.

The Participation of B Cells and Antibodies in the Selection and Maintenance of T Cell Repertoires

P. Pereira, A. Coutinho, M. Toribio, 1988, Immunological reviews.

A functional idiotypic network of T helper cells and antibodies, limited to the compartment of “naturally” activated lymphocytes in normal mice

P. Pereira, A. Coutinho, M. Toribio, 1987, European journal of immunology.

Isolation of peritoneal precursors of B‐1 cells in the adult mouse

A. Coutinho, M. Marcos, M. Marcos, 1994, European journal of immunology.

Immune Activation of B Cells: Evidence for‘One Nonspecific Triggering Signal' Not Delivered by the Ig Receptors

A. Coutinho, G. Möller, Göran Möller, 1974, Bollettino dell'Istituto sieroterapico milanese.

Hapten specific helper T cells restricted by theI-E(C) subregion of the MHC

A. Coutinho, C. Martínez-A, R. Bernabé, 1980, Immunogenetics.

Lamarckian inheritance by somatically acquired maternal IgG phenotypes.

A. Coutinho, H. Lemke, H. Lange, 2004, Trends in immunology.

Distinct helper activities control growth or maturation of B lymphocytes

A. Coutinho, S. Pettersson, A. Bandeira, 1983, European journal of immunology.

B-cell activation by helper cells is a two-step process

A. Coutinho, C. Martínez-A, 1981, Nature.

Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment.

A. Coutinho, R. Bernabé, P. Cazenave, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas' disease.

A. Coutinho, P. Minoprio, H. Eisen, 1986, Journal of immunology.

Very large and isotypically atypical polyclonal plaque‐forming cell responses in mice infected with Trypanosoma cruzi

A. Coutinho, H. Eisen, M. Joskowicz, 1985, European journal of immunology.

Negative selection of multireactive B cell clones in normal adult mice

A. Coutinho, A. Grandien, J. Andersson, 1994, European journal of immunology.

T cell dependence of the “natural” autoreactive B cell activation in the spleen of normal mice

P. Pereira, A. Coutinho, F. Huetz, 1988, European journal of immunology.

The high idiotypic connectivity of “natural” newborn antibodies is not found in adult mitogen‐reactive B cell repertoires

A. Coutinho, D. Holmberg, G. Wennerström, 1986, European journal of immunology.

Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen

A. Coutinho, L. Hammarström, E. Smith, 1976, The Journal of experimental medicine.

ACTIVATED BY LIPOPOLYSACCHARI DE TO SYNTHESIZE ANTIBODIES AGAINST THE TOLEROGEN

A. Coutinho, U. Persson, G. Möller, 1976 .

Ig‐Isotype Patterns of Primary and Secondary B Cell Responses to Plasmodium Chabaudi Chabaudi Correlate with IFN‐γ and IL‐4 Cytokine Production and with CD45RB Expression by CD4+ Spleen Cells

A. Coutinho, P. Minoprio, T. Kipnis, 1996, Scandinavian journal of immunology.

Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune‐protected mice

A. Coutinho, M. R. D’Império Lima, P. Falanga, 1987, European journal of immunology.

Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

A. Coutinho, M. Haury, J. Demengeot, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency

A. Coutinho, M. Carneiro-Sampaio, 2015, Front. Immunol..

Tolerance and autoimmunity: lessons at the bedside of primary immunodeficiencies.

A. Coutinho, M. Carneiro-Sampaio, 2007, Advances in immunology.

V-region connectivity in T cell repertoires.

P. Pereira, A. Coutinho, M. Toribio, 1989, Annual review of immunology.

IMMUNOLOGICAL CONSEQUENCES OF HIV INFECTION: ADVANTAGE OF BEING LOW RESPONDER CASTS DOUBTS ON VACCINE DEVELOPMENT

A. Coutinho, C. Martínez-A, J. Alonso, 1988, The Lancet.

Natural autoantibodies.

A. Coutinho, S. Avrameas, M. Kazatchkine, 1995, Current opinion in immunology.

Clonal analysis of B lymphocyte responses to Plasmodium chabaudi infection of normal and immunoprotected mice.

A. Coutinho, A. Freitas, T. Kipnis, 1991, International immunology.

Immunoglobulin C gene expression. IV. Alternative control of IgG1‐producing cells by helper cell‐derived B cell‐specific growth or maturation factors

A. Coutinho, S. Pettersson, L. Forni, 1983, European journal of immunology.

Isotype commitment in the in vivo immune responses. II. Polyclonal plaque‐forming cell responses to lipopolysaccharide in the spleen and bone marrow

A. Coutinho, Mariana Björklund, 1983, European journal of immunology.

Functional consequences of sheep red blood cell resetting for human T cells: Gain of reactivity to mitogenic factors

A. Coutinho, E. Larsson, J. Andersson, 1978, European journal of immunology.

MHC Class II Molecules Control Murine B Cell Responsiveness to Lipopolysaccharide Stimulation1

A. Coutinho, J. Demengeot, L. Gonçalves, 2006, The Journal of Immunology.

The Le Douarin phenomenon: a shift in the paradigm of developmental self-tolerance.

A. Coutinho, António Coutinho, 2005, The International journal of developmental biology.

Cancer Immunity: A Problem of Self-Tolerance

A. Coutinho, J. Demengeot, S. Hori, 2000 .

An example of idiotypic mimicry

A. Coutinho, A. Grandien, Jan Andersson, 1997, European journal of immunology.

The mutual selective influences of T- and B-cell repertoires: the idiotypic net (at) work.

P. Pereira, A. Coutinho, P. Cazenave, 1986, Annales de l'Institut Pasteur. Immunologie.

An experimental model for fatal malaria due to TNF-α-dependent hepatic damage

A. Coutinho, E. Seixas, P. Oliveira, 2008, Parasitology.

The allogeneic effect in vitro: activation of antibody synthesis in aggressor and target lymphocyte populations by allogeneic interaction

A. Coutinho, G. Möller, 1973, European journal of immunology.

in vitro induction of specific immune responses in the absence of serum: requirement for nonspecific t or b cell mitogens

A. Coutinho, G. Möller, 1973, European journal of immunology.

T cells which proliferate in response to concanavalin A include cells which proliferate in mixed leukocyte reactions

A. Coutinho, C. Fathman, T. Watanabe, 1977, European journal of immunology.

Vβ17 gene polymorphism in wild-derived mouse strains: Two amino acid substitutions in the Vβ17 region greatly alter T cell receptor specificity

A. Coutinho, F. Bonhomme, P. Cazenave, 1990, Cell.

Autoimmunity: the Moving Boundaries Between Physiology and Pathology

F. Varela, A. Coutinho, C. Rossi, 1989 .

Natural Immunological Tolerance: On Time and Space Again

A. Coutinho, A. Bandeira, 1997, Scandinavian journal of immunology.

A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens

A. Coutinho, A. Bandeira, Y. Modigliani, 1996, Immunological reviews.

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

A. Coutinho, C. Corbel, A. Bandeira, 1993, Immunological reviews.

Isotype commitment in the in vivo immune responses. I. Antigen- dependent specific and polyclonal plaque-forming cell responses by B lymphocytes induced to extensive proliferation

M. Björklund, A. Coutinho, Mariana Bjcirklund, 1982, The Journal of experimental medicine.

Reactions among IgM antibodies derived from normal, neonatal mice

A. Coutinho, D. Holmberg, F. Ivars, 1984, European journal of immunology.

Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults.

A. Coutinho, S. Kaveri, M. Kazatchkine, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Major histocompatibility complex‐linked and t cell‐dependent selection of antibody repertoires. quantitation of i‐e‐related specificities in normal mice*

P. Pereira, A. Coutinho, C. Rossi, 1989, European journal of immunology.

Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice

A. Coutinho, F. Melchers, K. Eichmann, 1977, The Journal of experimental medicine.

Frequencies of background immunoglobulin-secreting cells in mice as a function if organ, age, and immune status.

A. Coutinho, R. Bernabé, R. Benner, 1981, Immunobiology.

Mechanism of T cell activation I. A screening of “step one” ligands

A. Coutinho, E. Larsson, 1980, European journal of immunology.

Activation and growth requirements for cytotoxic and noncytotoxic T lymphocytes.

A. Coutinho, M. Gullberg, E. Larsson, 1984, Cellular immunology.

Regulation of T cell growth factor production: arrest of TCGF production after 18 hours in normal lectin-stimulated mouse spleen cell cultures.

A. Coutinho, M. Gullberg, E. Larsson, 1981, Journal of immunology.

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

A. Coutinho, A. Bandeira, M. Coltey, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Autoimmunity : physiology and disease

A. Coutinho, M. Kazatchkine, 1993 .

T-cell-dependent modulation of the polyclonal B-lymphocyte responses in normal spleen cell cultures stimulated by lipopolysaccharide.

M. Björklund, A. Coutinho, L. Forni, 1987, Annales de l'Institut Pasteur. Immunology.

Heterogeneity of cells and factors participating in the concanavalin A-dependent activation of T lymphocytes with cytotoxic potential.

A. Coutinho, M. Gullberg, E. Larsson, 1982, Immunobiology.

Suppressor versus Cytolytic CD8+ T Lymphocytes: Where are the Artefacts?

P. Pereira, A. Coutinho, A. Bandeira, 1988, Scandinavian journal of immunology.

“In vivo” activated splenic T cells are refractory to interleukin 2 growth “in vitro”

P. Pereira, A. Coutinho, L. Forni, 1987, European journal of immunology.

Some reasons why deletion and anergy do not satisfactorily account for natural tolerance.

A. Coutinho, A. Grandien, A. Bandeira, 1992, Research in immunology.

Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease.

A. Coutinho, P. Minoprio, M. Hontebeyrie-Joskowicz, 1991, International Immunology.

Suppression of B cell differentiation by ligation of membrane‐bound IgM

A. Coutinho, A. Grandien, Jan Andersson, 1993, European journal of immunology.

Preferential expansion of Ly-1 B and CD4- CD8- T cells in the polyclonal lymphocyte responses to murine T. cruzi infection.

P. Pereira, A. Coutinho, P. Minoprio, 1989, International immunology.

Maternal IgG stimulates B lineage cell development in the progeny

A. Coutinho, E. Malanchère, F. Huetz, 1997, European journal of immunology.

Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection

A. Coutinho, B. Reina-San-Martin, P. Minoprio, 2001, European journal of immunology.

The Immune Response to Bacterial Dextrans

A. Coutinho, I. Lundkvist, D. Portnoï, 1989, Scandinavian journal of immunology.

Antigen‐independent, IgM‐induced antibody responses: requirement for “recurrent” idiotypes

A. Coutinho, D. Holmberg, L. Forni, 1982, European journal of immunology.

Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice

A. Coutinho, D. Holmberg, A. Freitas, 1986, The Journal of experimental medicine.

Quantitative Evidence Against Inactivation of Self‐Reactive B‐Cell Clones

A. Coutinho, S. Avrameas, P. Lymberi, 1986, Scandinavian journal of immunology.

Selection of lymphocyte repertoires: the limits of clonal versus network organization.

P. Pereira, A. Coutinho, D. Holmberg, 1989, Cold Spring Harbor symposia on quantitative biology.

Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs.

A. Coutinho, B. Rocha, A. Freitas, 1983, Journal of immunology.

Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

A. Coutinho, C. Penha-Gonçalves, Roberto Lardoeyt, 2015, Malaria Journal.

Role of B and T lymphocytes in the specific immunosuppression induced by a protein released by porcine monocytes infected with African swine fever virus.

A. Coutinho, M. Vilanova, M. Porto, 1991, International immunology.

Functional and Chemical Characterization of B‐Cell Growth Factor Produced by Normal Cloned T Helper Cells

A. Coutinho, S. Pettersson, G. Pobor, 1984, Scandinavian journal of immunology.

From the mechanisms of lymphocyte activation to internal activity in the immune system.

M. Björklund, A. Coutinho, D. Holmberg, 1983, Annales d'immunologie.

Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti‐immunoglobulin antibodies

A. Coutinho, F. Melchers, J. Andersson, 1978, European journal of immunology.

The membrane receptor complex regulating induction and clonal expansion of normal murine B lymphocytes.

A. Coutinho, L. Forni, C. Martínez, 1984, Reviews of infectious diseases.

A Model System for the Analysis of B‐Cell Activation and Effector T‐Cell Functions

P. Pereira, A. Coutinho, C. Martínez-A, 1989, Scandinavian journal of immunology.

Intraclonal diversification in immunoglobulin isotype secretion: an analysis of switch probabilities.

A. Coutinho, L. Forni, 1982, The EMBO journal.

Major histocompatibility complex‐restricted and unrestricted T helper cells recognizing minor histocompatibility antigens of B cell surfaces

A. Coutinho, A. Augustin, 1980, European journal of immunology.

Growth and maturation of single clones of normal murine T and B lymphocytes in vitro.

A. Coutinho, F. Melchers, J. Andersson, 1977, Cold Spring Harbor symposia on quantitative biology.

Continuous Growth of Mitogen‐Reactive B Lymphocytes

A. Coutinho, F. Melchers, G. Heinrich, 1975, Scandinavian journal of immunology.

Immunoglobulin isotype expression II. Frequency analysis in mitogen‐reactive B cells

Robbert Benner, A. Coutinho, R. Benner, 1981, European journal of immunology.

Characterization of mouse thoracic duct B lymphocytes I. Evidence of functional heterogeneity

A. Coutinho, A. Freitas, 1980, European journal of immunology.

The switch from IgM to IgG secretion in single mitogen-stimulated B- cell clones

A. Coutinho, F. Melchers, J. Andersson, 1978, The Journal of experimental medicine.

Natural effector T lymphocytes in normal mice.

P. Pereira, A. Coutinho, L. Forni, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Effect of Anti-δ Antibodies on Clonal Expansion and Maturation of B Lymphocytes

A. Coutinho, C. Martínez-A, R. Bernabé, 1981 .

Immune response to bacterial dextrans. II. T cell control of antibody isotypes

A. Coutinho, D. Holmberg, F. Ivars, 1983, The Journal of experimental medicine.

Functional Analysis of Pokeweed Mitogen‐Dependent Cell Interactions in Murine Spleen Cells

A. Coutinho, M. Gullberg, A. Bandeira, 1985, Scandinavian journal of immunology.

Role of the humoral immune response in resistance to Theiler's virus infection

A. Coutinho, C. Rossi, E. Cash, 1991, Journal of virology.

Strong mitogenic effect for murine B lymphocytes of an immunosuppressor substance released by Streptococcus intermedius

A. Coutinho, M. Santarem, M. Arala-Chaves, 1986, Infection and immunity.

Ontogenic development of “natural” and induced plaque‐forming cell isotypes in normal mice

A. Coutinho, S. Pettersson, M. Bjorklund, 1985, European journal of immunology.

From the point of view of an immunologist: enemies from within or friends from long ago?

A. Coutinho, Antonio Coutinho, 1982, Current topics in microbiology and immunology.

Quantitative analysis of multiple V‐region interactions among normal human IgG

A. Coutinho, A. Ayouba, G. Peltre, 1996, European journal of immunology.

ARE ACTIVATED CYCLING CELLS IN NORMAL MICE

A. Coutinho, D. Holmberg, A. Freitas, 1986 .

Proliferative T cell anergy to MIs-1a does not correlate with in vivo tolerance.

A. Coutinho, A. Bandeira, J. Mengel, 1991, International immunology.

Hemorrhage in mice produces alterations in B cell repertoires.

A. Coutinho, E. Abraham, A. Freitas, 1989, Cellular immunology.

Inverse correlation between the utilization of an idiotype in specific immune responses and its representation in pre‐immune “natural” antibodies

A. Coutinho, I. Lundkvist, D. Portnoi, 1988, European journal of immunology.

Selection of antibody repertoires by anti-idiotypes can occur at multiple steps of B cell differentiation.

A. Coutinho, A. Freitas, O. Burlen, 1988, Journal of immunology.

On the Validity of Using Lipopolysaccharide‐Driven Limiting Dilution Systems for Clonable B‐Cells to Analyse Functional Antibody Repertoires

A. Coutinho, I. Lundkvist, D. Portnoï, 1988, Scandinavian journal of immunology.

Long‐lived B cells: mitogen reactivity as a tool for studying their life‐spans

A. Coutinho, M. Lévy, 1987, European journal of immunology.

UNCORRECTED PROOF 1Q1 Fetal-onset IPEX: Report of two families and 2 review of literature

A. Coutinho, C. Moreira-Filho, M. Carneiro-Sampaio, 2014 .

Observations on the Mode of Action of Normal Immunoglobulin at High Doses

A. Coutinho, M. Haury, A. Freitas, 1994, Immunological reviews.

Suppression of antibody responses to the acetylcholine receptor by natural antibodies

A. Coutinho, S. Hauser, D. Holmberg, 1989, European journal of immunology.

Selective expansion of idiotype sharing T and B cells in cyclosporin A-mediated autoimmunity.

P. Pereira, A. Coutinho, M. Toribio, 1991, International immunology.

Tolerize one, tolerize them all: tolerance is self-assertion.

A. Coutinho, A. Bandeira, Antonio Bandeira, 1989, Immunology today.

A Missing Dimension in Measures of Vaccination Impacts

M. Lipsitch, A. Coutinho, G. Medley, 2014, PLoS pathogens.

Immune networks: getting on to the real thing.

F. Varela, A. Coutinho, A Coutinho, 1989, Research in immunology.

The Self‐Reactive Antibody Repertoire of Normal Human Serum IgM is Acquired in Early Childhood and Remains Conserved Throughout Life

A. Coutinho, S. Lacroix-Desmazes, M. Kazatchkine, 1996, Scandinavian journal of immunology.

Regulatory T cells in microbial infection

A. Coutinho, I. Caramalho, S. Zelenay, 2006, Springer Seminars in Immunopathology.

The blind‐spot of regulatory T cells

A. Coutinho, L. Graça, B. Silva-Santos, 2006, European journal of immunology.

Responsiveness of Lymphoid Precursors to Polyclonal B‐Cell Activators

A. Coutinho, E. Gronowicz, 1975, Scandinavian journal of immunology.

The polyclonal expression of immunoglobulin variable region determinants on the membrane of B cells and their precursors

A. Coutinho, R. Bernabé, L. Forni, 1980, Springer Seminars in Immunopathology.

Regulation of In Vitro Immunocyte Activation

A. Coutinho, U. Persson, G. Möller, 1977, Scandinavian journal of immunology.

Natural lymphocyte activation in postnatal development of germ-free and conventional mice.

A. Coutinho, C. Heusser, L. Forni, 1988, Annales de l'Institut Pasteur. Immunology.

Type I IFN sets the stringency of B cell repertoire selection in the bone marrow.

A. Coutinho, J. Demengeot, R. Vasconcellos, 1999, International immunology.

IgM antibodies induce the production of antibodies of the same specificity.

N. K. Jerne, A. Coutinho, G. Köhler, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Rearrangement and expression of Vγ1, Vγ2 and Vγ3 TCR γ genes in C57BL/6 mice

S. Tonegawa, P. Pereira, A. Coutinho, 1996 .

The Network Theory: 21 Years Later

A. Coutinho, A Coutinho, 1995, Scandinavian journal of immunology.

Allogeneic H‐2 does not Cross‐react, at the Helper T‐Cell Level, with Hapten‐modified Self

A. Coutinho, R. Bernabé, C. Martínez, 1981, Scandinavian journal of immunology.

Is the Network Theory Tautologic

A. Coutinho, D. Holmberg, L. Forni, 1983 .

Skewed Vβ TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection

A. Coutinho, P. Minoprio, H. Eisen, 1994 .

Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection.

A. Coutinho, P. Minoprio, H. Eisen, 1994, International Immunology.

Rearrangement and expression of Vzeta1, Vzeta2 and Vzeta3 TCR zeta genes in C57BL/6 mice.

S. Tonegawa, P. Pereira, A. Coutinho, 1996, International Immunology.

Experimental and Theoretical Investigations on Idiotypic Mimicry

A. Coutinho, J. Stewart, A. Grandien, 1992 .

Long‐lasting thymus‐independent immune responses to anti‐idiotype lipopolysaccharide conjugates require continuous B cell renewal

A. Coutinho, A. Freitas, O. Burlen, 1988, European journal of immunology.

Idiotypic characterization of antibody-induced antibody responses.

A. Coutinho, D. Holmberg, P. Cazenave, 1982, Immunobiology.

The Theory of the‘One Nonspecific Signal’Model for B Cell Activation

A. Coutinho, Antonio Coutinho, 1975, Transplantation reviews.

Regeneration of Natural Antibody Repertoire After Massive Ablation of Lymphoid System: Robust Selection Mechanisms Preserve Antigen Binding Specificities1

A. Coutinho, B. Stransky, N. Nicolas, 2002, The Journal of Immunology.

Antigen Binding Specificities Robust Selection Mechanisms Preserve After Massive Ablation of Lymphoid System : Regeneration of Natural Antibody Repertoire

A. Coutinho, B. Stransky, N. Nicolas, 2002 .

Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues.

A. Coutinho, M. Haury, S. Lacroix-Desmazes, 1995, Journal of immunology.

Population dynamics of natural antibodies in normal and autoimmune individuals.

F. Varela, A. Coutinho, M. Kazatchkine, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Speculations on Immunosomatics: Potential Diagnostic and Therapeutic Value of Immune Homeostasis Concepts

A. Coutinho, S. Avrameas, 1992, Scandinavian journal of immunology.

Genetic control of natural antibody repertoires: I. IgH, MHC and TCRβ loci

A. Coutinho, M. Haury, R. Vasconcellos, 1998, European Journal of Immunology.

Global Analysis of Antibody Repertoires. 1. An Immunoblot Method for the Quantitative Screening of a Large Number of Reactivities

A. Coutinho, M. Haury, A. Grandien, 1994, Scandinavian journal of immunology.

Antigen-specific and -non-specific regulatory influences of antibody in immune responses are determined by variable region properties.

A. Coutinho, L. Forni, 1981, Annales d'immunologie.

Origin of CD5+ B cells and natural IgM‐secreting cells: reconstitution potential of adult bone marrow, spleen and peritoneal cells

A. Coutinho, V. Thomas-Vaslin, F. Huetz, 1992, European journal of immunology.

Quantitative aspects of the nonspecific humoral immune response to sheep erythrocytes.

A. Coutinho, R. Benner, A. van Oudenaren, 1982, Advances in experimental medicine and biology.

Very rapid decay of mature B lymphocytes in the spleen

A. Coutinho, A. de Freitas, A A de Freitas, 1981, The Journal of experimental medicine.

Effector functions and specificities of normal murine T cells stimulated by syngeneic blasts

A. Coutinho, M. Gullberg, A. Beretta, 1986, European journal of immunology.

Differential L chain expression in the antibody responses to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes.

A. Coutinho, P. Cazenave, C. Martínez, 1989, Journal of immunology.

Selectivity of recognition of variable (V) regions of autoantibodies by intravenous immunoglobulin (IVIg).

A. Coutinho, M. Haury, M. Kazatchkine, 1994, Clinical immunology and immunopathology.

Idiotypic determinants of natural IgM antibodies that resemble self Ia antigens.

A. Coutinho, D. Holmberg, L. Forni, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Ontogenic development of autoantibody repertoires in spleen and peritoneal cavity of normal mice: examples of T cell‐dependent and ‐independent reactivities

A. Coutinho, P. Poncet, F. Huetz, 1989, European journal of immunology.

A Quantitative Assay Detecting Small Numbers of Effector Helper T Cells, Regardless of Clonal Specificity

A. Coutinho, S. Pettersson, A. Bandeira, 1984, Scandinavian journal of immunology.

An example of major histocompatibility complex‐linked control of idiotypic interactions

A. Coutinho, D. Holmberg, F. Ivars, 1983, European journal of immunology.

Immunophenotypic aberrations, DNA content, and cell cycle analysis of plasma cells in patients with myeloma and monoclonal gammopathies.

Ana Helena Santos, A. Coutinho, M. Lima, 2000, Blood cells, molecules & diseases.

Development of B Cells secreting Endogenous or Transgene‐Encoded Immunoglobulins in H‐Chain Transgenic Mice

A. Coutinho, A. Grandien, J. Andersson, 1993, Scandinavian journal of immunology.

On the origin of natural IgM in immunoglobulin transgenic mice.

A. Coutinho, A. Grandien, A. Freitas, 1992, International Immunology.

Coelomic and Bone Marrow‐Derived B Cells

A. Coutinho, C. Martínez-A, A. Grandien, 1992 .

What is the Immune Network For

F. Varela, A. Coutinho, J. Stewart, 2018 .

Dynamics of serum IgM autoreactive repertoires following immunization: strain specificity, inheritance and association with autoimmune disease susceptibility

A. Coutinho, C. Fesel, 1998, European journal of immunology.

Genetic control of natural antibody repertoires: I. IgH, MHC and TCRβ loci

A. Coutinho, M. Haury, R. Vasconcellos, 1998, European journal of immunology.

The Affirmation of Self: A New Perspective on the Immune System

John Stewart, António Coutinho, A. Coutinho, 2004, Artificial Life.

The origin of "natural antibodies" and the internal activity in the immune system.

P. Pereira, A. Coutinho, A. Bandeira, 1988, International reviews of immunology.

Maternal IgG stimulates B lineage cell development in the progeny

A. Coutinho, E. Malanchère, F. Huetz, 1997, European journal of immunology.

Instability of Natural Antibody Repertoires in Systemic Lupus Erythematosus Patients, Revealed by Multiparametric Analysis of Serum Antibody Reactivities

A. Coutinho, M. Haury, M. Kazatchkine, 1997, Scandinavian journal of immunology.

Studies on the T cell dependence of natural IgM and IgG antibody repertoires in adult mice

A. Coutinho, E. Malanchère, M. Marcos, 1995, European journal of immunology.

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse

A. Coutinho, J. Demengeot, J. Corte-Real, 2009, Genes and Immunity.

Physiopathology of Autoimmunity: The Reactivities of Natural Antibodies Define the Boundaries of the Immunological Self

A. Coutinho, M. Haury, A. Sundblad, 1993 .

Germ-line selection ensures embryonic autoreactivity and a positive discrimination of self mediated by supraclonal mechanisms.

A. Coutinho, 2000, Seminars in immunology.

Distinguishable Patterns of Connectivity in Serum Immunoglobulins from SLE Patients and Healthy Individuals

A. Coutinho, A. Ayouba, C. Ferreira, 1997, Scandinavian journal of immunology.

Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states

A. Coutinho, C. Martínez-A, R. Bernabé, 1981, The Journal of experimental medicine.

Frequencies ofAntibody- and Idiotype-producing B Cell Clones in Various Steady States*

A. Coutinho, C. Martínez-A, P. Cazenave, 1981 .

Expression of V-region-like determinants on Ig-negative precursors in murine fetal liver and bone marrow

A. Coutinho, P. Cazenave, L. Forni, 1979, Nature.

Turning (Ir gene) low responders into high responders by antibody manipulation of the developing immune system.

P A Cazenave, P. Pereira, A. Coutinho, 1987, Proceedings of the National Academy of Sciences of the United States of America.

11 – A Helper Cell Assay of Cellular Antigens and Its Applications to Hapten-Specific T Cells

A. Coutinho, C. Martínez-A, A. Augustin, 1981 .

Simple developmental programs of gene expression and cellular composition of lymphoid organs at the origin of natural tolerance.

A. Coutinho, 1995, Research in Immunology.

IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei–Infected Mice

A. Coutinho, C. Penha-Gonçalves, M. Sambo, 2013, The Journal of Immunology.

Old dogs and new tricks: Defective peripheral regulatory T cell generation in aged mice

A. Coutinho, Thiago Lopes-Carvalho, 2013, European journal of immunology.

Anti-Ia.7 antibodies recognize a "major" idiotype of the anti-TNP antibody response in BALB/c mice.

A. Coutinho, D. Holmberg, F. Ivars, 1984, Annales d'immunologie.

MECHANISM OF THYMUS-INDEPENDENT IMMUNOCYTE TRIGGERING

A. Coutinho, G. Möller, W. W. Bullock, 1974, The Journal of experimental medicine.

Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen

A. Coutinho, L. Hammarström, E. Smith, 1976, The Journal of experimental medicine.

Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

A. Coutinho, C. Penha-Gonçalves, Roberto Lardoeyt, 2015, Malaria Journal.

The enhancement of antibody response by IgM antibodies is dependent on antigen-specific T helper cells.

A. Coutinho, L. Forni, 1981, Immunobiology.

The Self‐Nonself Discrimination: A One‐Signal Mechanism

A. Coutinho, Göran Möller, 1975, Scandinavian journal of immunology.

Role of the humoral immune response in resistance to Theiler's virus infection

A. Coutinho, E. Cash, C. Aubert, 1991, Journal of Virology.