A computational approach to memory deficits in schizophrenia

Episodic memory impairment is one of the most reliable neuropsychological !ndings in schizophrenia. It has been suggestedthat med ial temporal lobe abnormalities in schizophrenia underlie this impairment. We suggest that the speci!c memory de!cits in schizophrenia may be causedby abnormal hippocampo-cortical communication via parahippocampal areas. We have usedconnectionist simulations to investigate this notion. The simulations involve list learning in a model that incorporates characteristics of the hippocampal and parahippocampal region. In this model context is used to store and recall episodic memories. Reduction of the nodes in the parahippocampal module of the model resulted in a schizophrenia-like memory de!cit pro!le. c � 2002 Publishedby Elsevier Science B.V.

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