Molecular Function Prediction for a Family Exhibiting Evolutionary Tendencies Towards Substrate Specificity Swapping : Recurrence of Tyrosine Aminotransferase Activity in the I α Subfamily Short Title : Aminotransferase Substrate Specificity Swapping Keywords : Enzyme , Kinetics , Phylogenetics , Py

1 Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America 2 Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California, United States of America 3 Current affiliation: Biostatistics & Bioinformatics Department, Department of Statistical Science, Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, United States of America 4 Department of Statistics, University of California, Berkeley, California, United States of America 5 Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America Research Article Proteins: Structure, Function and Bioinformatics DOI 10.1002/prot.24318

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