Probabilistic classification learning in amnesia.

Amnesic patients and control subjects participated in a study of probabilistic classification learning. In each of three tasks, four different cues were each probabilistically associated with one of two outcomes. On each trial, the cues could appear alone or in combination with other cues and subjects selected the outcome they thought was correct. Feedback was provided after each trial. In each task, the amnesic patients learned gradually to associate the cues with the appropriate outcome at the same rate as control subjects, improving from 50% correct to approximately 65% correct. Presumably because the cue-outcome associations were probabilistic, declarative memory for the outcomes of specific trials was not as useful for performance as the information gradually accrued across trials. Nevertheless, declarative memory does appear to make a contribution to performance when training is extended beyond approximately 50 trials, because with further training control subjects eventually outperformed the amnesic patients. It was also demonstrated that performance on the probabilistic classification task was not the result of holding knowledge of cue-outcome associations in short-term memory, because both control subjects and amnesic patients demonstrated significant savings when testing was interrupted by a 5-min delay (experiment 2). Probabilistic classification learning appears to provide an analog in human subjects for the habit learning tasks that can be acquired normally by animals with hippocampal lesions.

[1]  P. Osterrieth Le test de copie d'une figure complexe , 1944 .

[2]  R. Atkinson,et al.  Probabilistic discrimination learning. , 1957, Journal of experimental psychology.

[3]  C. Shimp Probabilistically reinforced choice behavior in pigeons. , 1966, Journal of the experimental analysis of behavior.

[4]  Weitzman Ra Positional matching in rats and fish. , 1967 .

[5]  J. G. Gilbert,et al.  A Preliminary Report on a New Memory Scale , 1968, Perceptual and motor skills.

[6]  A. Baddeley,et al.  Amnesia and the distinction between long- and short-term memory. , 1970 .

[7]  William K. Estes,et al.  Research and Theory on the Learning of Probabilities , 1972 .

[8]  R. Rescorla,et al.  A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement , 1972 .

[9]  E. Kaplan,et al.  The Boston naming test , 2001 .

[10]  L. Squire,et al.  Preserved learning in monkeys with medial temporal lesions: sparing of motor and cognitive skills , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  D. Broadbent,et al.  On the Relationship between Task Performance and Associated Verbalizable Knowledge , 1984 .

[12]  M. Mishkin,et al.  Monkeys with combined amygdalo-hippocampal lesions succeed in object discrimination learning despite 24-hour intertrial intervals. , 1984, Behavioral neuroscience.

[13]  L. Squire,et al.  Characterizing amnesic patients for neurobehavioral study. , 1986, Behavioral neuroscience.

[14]  L. Squire Memory and Brain , 1987 .

[15]  J. Saint-Cyr,et al.  Procedural learning and neostriatal dysfunction in man. , 1988, Brain : a journal of neurology.

[16]  L. Squire,et al.  Human amnesia and animal models of amnesia: performance of amnesic patients on tests designed for the monkey. , 1988, Behavioral neuroscience.

[17]  L. Squire,et al.  Transient global amnesia , 1988, Neurology.

[18]  G. Bower,et al.  Evaluating an adaptive network model of human learning , 1988 .

[19]  Impaired learning of a motor skill in patients with Huntington's disease. , 1988, Behavioral neuroscience.

[20]  G. Bower,et al.  From conditioning to category learning: an adaptive network model. , 1988 .

[21]  A. Mayes,et al.  Human organic memory disorders , 1988 .

[22]  M. Packard,et al.  Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  W. Estes,et al.  Base-rate effects in category learning: a comparison of parallel network and memory storage-retrieval models. , 1989, Journal of experimental psychology. Learning, memory, and cognition.

[24]  D. Salmon,et al.  Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's, and Parkinson's disease patients , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  A. Markman LMS rules and the inverse base-rate effect: Comment on Gluck and Bower (1988). , 1989 .

[26]  A P Shimamura,et al.  Cognitive impairment following frontal lobe damage and its relevance to human amnesia. , 1989, Behavioral neuroscience.

[27]  L. Squire,et al.  Intact text-specific reading skill in amnesia. , 1990, Journal of experimental psychology. Learning, memory, and cognition.

[28]  R. F. Thompson,et al.  Neural mechanisms of classical conditioning in mammals. , 1990, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[29]  L. Squire,et al.  Cognitive skill learning in amnesia , 1990, Psychobiology.

[30]  G A Press,et al.  Magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medial temporal lobe and diencephalic amnesia , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[31]  Mark A. Gluck,et al.  Component and pattern information in adaptive networks , 1990 .

[32]  David R. Shanks,et al.  CATEGORIZATION BY A CONNECTIONIST NETWORK , 1991 .

[33]  David R. Shanks,et al.  CATEGORIZATION BY A CONNECTIONIST NETWORK , 1991 .

[34]  W. K. Estes,et al.  COGNITIVE ARCHITECTURES FROM THE STANDPOINT OF AN EXPERIMENTAL PSYCHOLOGIST , 1991 .

[35]  M. Nissen,et al.  Procedural learning is impaired in Huntington's disease: Evidence from the serial reaction time task , 1991, Neuropsychologia.

[36]  N Butters,et al.  The biasing of weight judgments in Alzheimer's and Huntington's disease: a priming or programming phenomenon. , 1991, Journal of clinical and experimental neuropsychology.

[37]  F M Miezin,et al.  Activation of the hippocampus in normal humans: a functional anatomical study of memory. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[38]  C. B. Cave,et al.  Intact and long-lasting repetition priming in amnesia. , 1992, Journal of experimental psychology. Learning, memory, and cognition.

[39]  Seth J. Ramus,et al.  Intact Artificial Grammar Learning in Amnesia: Dissociation of Classification Learning and Explicit Memory for Specific Instances , 1992 .

[40]  L. Squire,et al.  P300 from amnesic patients with bilateral hippocampal lesions. , 1993, Electroencephalography and clinical neurophysiology.

[41]  L. Squire,et al.  The structure and organization of memory. , 1993, Annual review of psychology.

[42]  D. Schacter,et al.  Implicit memory: a selective review. , 1993, Annual review of neuroscience.

[43]  M. Gluck,et al.  Hippocampal mediation of stimulus representation: A computational theory , 1993, Hippocampus.

[44]  L. Squire,et al.  The learning of categories: parallel brain systems for item memory and category knowledge. , 1993, Science.

[45]  L R Squire,et al.  The information acquired during artificial grammar learning. , 1994, Journal of experimental psychology. Learning, memory, and cognition.