Homosynaptic long-term depression in hippocampus and mescsrtex

Summary Finding evidence for homosynaptic LTD in the brain is an important first step but we are still a long way from understanding its significance. More needs to be known about the timing relationships that produce these phenomena, as well as the spatial integration of synaptic signals within dendritic trees. The conditions for eliciting homosynaptic LTD are more delicate than those for inducing LTP, perhaps because the range of postsynaptic membrane potentials that elicit LTD is relatively narrow.26 This suggests that cortical structures store cova~iance information by finely regulating dendritic membrane potentials around the thresholds for LTD and LTP. Unfortunately, it is not possible at present to explore these possibilities by measuring or controlling accurately dendritic potentials in cortical neurons. Models of dendritic processing may be needed to sharpen our intuitions and help us to interpret other experimental results. 58 Acknowledgements This research was supported by grants from the Mathers Foundation, the Drown Foundation and the Office of Naval Research to T. J. S., and an Office of Naval Research Young Investigator Award and Klingenstein Foundation Fellowship to P. K. S.

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