Early development of visual cortical cells in normal and dark‐reared kittens: relationship between orientation selectivity and ocular dominance.

1. 535 units were recorded in the primary visual cortex in twelve normally reared and fifteen dark‐reared kittens aged between 8 and 50 days. These results were pooled with a previous study of 582 units recorded from thirty‐five kittens reared in similar conditions. 2. These 1117 cells were classified into four functional classes of neurones: (a) visually unresponsive cells, (b) non‐specific cells which were sensitive to spots or slits of light moving in any direction, (c) immature cells which were preferentially activated by a rectilinear stimulus but unselective regarding its precise orientation and (d) specific cells that appeared to be as selective for orientation as the simple or complex cells in the adult cat. 3. The results confirm that cells having the same orientation‐specific response properties as adult cortical visual neurones are present in the earliest stages of post‐natal development, independently of visual experience. However, to maintain and develop these specific cells after the third week of post‐natal life, visual experience is necessary. 4. The ocular dominance of visual cells is not constant from the earliest stages of development. A significant increase in binocularly driven neurones occurs with age. 5. Before 3 weeks of age, whatever the rearing conditions, there are more specific cells coding horizontal and vertical orientations than those coding oblique orientations. These 'horizontal and vertical detectors' are preferentially driven by the contralateral eye. 5. After 4 weeks of age, specific neurones are found at all orientations in normally reared kittens. At this stage of development the ocular dominance is independent of orientation preference, of the functional class of neurones considered and of the rearing conditions. The proportion of binocularly driven cells is slightly below adult standard. 7. A hypothesis of differential plasticity is proposed: contralateral, monocular 'horizontal and vertical detectors' are supposed to be stable; they would remain so until they become binocular. Binocular cells, for which competition between two inputs occurs, are the labile units which can be despecified or specified under the control of visual experience.

[1]  D. Hubel,et al.  Receptive fields of single neurones in the cat's striate cortex , 1959, The Journal of physiology.

[2]  D. Hubel,et al.  Receptive fields, binocular interaction and functional architecture in the cat's visual cortex , 1962, The Journal of physiology.

[3]  D. Hubel,et al.  RECEPTIVE FIELDS OF CELLS IN STRIATE CORTEX OF VERY YOUNG, VISUALLY INEXPERIENCED KITTENS. , 1963, Journal of neurophysiology.

[4]  D. Hubel,et al.  Shape and arrangement of columns in cat's striate cortex , 1963, The Journal of physiology.

[5]  G. H. Rose.  A stereotaxic apparatus for the developing kitten brain. , 1970, Physiology & behavior.

[6]  H. Barlow,et al.  Lack of specificity of neurones in the visual cortex of young kittens. , 1971, The Journal of physiology.

[7]  F. Campbell,et al.  The contrast sensitivity of the cat , 1973, The Journal of physiology.

[8]  D. Hubel,et al.  Sequence regularity and geometry of orientation columns in the monkey striate cortex , 1974, The Journal of comparative neurology.

[9]  P. O. Bishop,et al.  Orientation specificity of cells in cat striate cortex. , 1974, Journal of neurophysiology.

[10]  B. Cragg,et al.  Plasticity of synapses. , 1974, British medical bulletin.

[11]  J. Pettigrew,et al.  The effect of visual experience on the development of stimulus specificity by kitten cortical neurones , 1974, The Journal of physiology.

[12]  H. B. Barlow,et al.  Visual experience and cortical development , 1975, Nature.

[13]  C. Blakemore,et al.  Innate and environmental factors in the development of the kitten's visual cortex. , 1975, The Journal of physiology.

[14]  K. Albus.  Predominance of monocularly driven cells in the projection area of the central visual field in cat's striate cortex , 1975, Brain Research.

[15]  P. Grobstein,et al.  Receptive field development and individual experience , 1975, Science.

[16]  K. Albus.  A quantitative study of the projection area of the central and the paracentral visual field in area 17 of the cat , 1975, Experimental brain research.

[17]  M. Stryker,et al.  Modification of cortical orientation selectivity in the cat by restricted visual experience: a reexamination , 1975, Science.

[18]  M. Stryker,et al.  Quantitative study of cortical orientation selectivity in visually inexperienced kitten. , 1976, Journal of neurophysiology.

[19]  Thorn Frank,et al.  The development of the kitten's visual optics , 1976, Vision Research.

[20]  M. Imbert,et al.  Visual cortical cells: their developmental properties in normal and dark reared kittens. , 1976, The Journal of physiology.

[21]  P. D. Spear,et al.  Effects of visual deprivation and alterations in binocular competition on responses of striate cortex neurons in the cat , 1976, The Journal of comparative neurology.

[22]  S. Sherman,et al.  Receptive-field characteristics of neurons in cat striate cortex: Changes with visual field eccentricity. , 1976, Journal of neurophysiology.

[23]  R. Anker.  The prenatal development of some of the visual pathways in the cat , 1977, The Journal of comparative neurology.

[24]  H. Hirsch,et al.  Effects of early experience upon orientation sensitivity and binocularity of neurons in visual cortex of cats. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Mitchell,et al.  A physiological and behavioural study in cats of the effect of early visual experience with contours of a single orientation. , 1977, The Journal of physiology.