A permissible region extraction based on a knowledge priori for X-ray luminescence computed tomography

X-ray luminescence computed tomography (XLCT) is a promising imaging technology for biological applications. The reconstruction, however, suffers from severe ill-posedness due to the strong scattering of photon propagation in biological tissues. A permissible region (PR) extraction based on a knowledge priori is proposed to alleviate the ill-posedness in this paper. N groups of recovered result with N groups of different discretized mesh have provided N groups of PR for XLCT, which can be considered as a knowledge priori. The intersection of N groups of PR provides a reasonable PR of nanophosphor. With the PR, an improved recovered result can be obtained. Numerical simulation experiments and physical phantom experiments on a cylinder have demonstrated the feasibility and effectiveness of this strategy.

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