A dynamic model of learning in the septo-hippocampal system

Abstract Gluck and Myers (Hippocampus 3 (1993) 491–516) modeled the hippocampus as an auto-encoder; Myers et al. (Neurobiol. Learning Memory 66 (1996) 51–66) argued that the cholinergic input from medial septum modulates learning rate in this auto-encoder. Neurophysiological evidence suggests the hippocampus self-regulates septal acetylcholine release in response to novel stimuli (Hasselmo and Schnell, J. Neurosci. 14 (1994) 3898–3914). We have extended our earlier model of septohippocampal modulation to include such a feedback loop. The resulting dynamic model learns faster and better than the earlier version on phenomena such as blocking and shift reversal. It can also be applied to data regarding the effects of the anticholinergic drug scopolamine.

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