A Novel Measure for Synchrony and its Application to Neural Signals

A novel measure to quantify the synchrony between two sparse binary strings is proposed, referred to as "stochastic event synchrony" (SES). It is computed by performing inference in a probabilistic model. SES can amongst other be used to detect synchrony in neural signals, in particular, spike trains (obtained from electrophysiological recordings) and EEG signals. It is demonstrated how SES can quantify the firing reliability of a neuron. It is also shown how SES can be used as a feature to detect Alzheimer's disease based on EEG signals.

[1]  E. Harth,et al.  Electric Fields of the Brain: The Neurophysics of Eeg , 2005 .

[2]  Rémi Gervais,et al.  A machine learning approach to the analysis of time-frequency maps, and its application to neural dynamics , 2007, Neural Networks.

[3]  J. Martinerie,et al.  The brainweb: Phase synchronization and large-scale integration , 2001, Nature Reviews Neuroscience.

[4]  H. Robinson The Biophysical Basis of Firing Variability in Cortical Neurons , 2003 .

[5]  F. Vialatte Modélisation en bosses pour l'analyse de motifs oscillatoires reproductibles dans l'activité de populations neuronales: applications à l'apprentissage olfactif chez l'animal et à la détection précoce de la maladie d'Alzheimer , 2005 .

[6]  H.-A. Loeliger,et al.  An introduction to factor graphs , 2004, IEEE Signal Processing Magazine.

[7]  D. Rubin,et al.  Maximum likelihood from incomplete data via the EM - algorithm plus discussions on the paper , 1977 .

[8]  Andrzej Cichocki,et al.  Sparse Bump Sonification: A New Tool for Multichannel EEG Diagnosis of Mental Disorders; Application to the Detection of the Early Stage of Alzheimer's Disease , 2006, ICONIP.

[9]  Yutaka Sakai,et al.  Synchronous Firing and Higher-Order Interactions in Neuron Pool , 2003, Neural Computation.

[10]  P. Stoica,et al.  Cyclic minimizers, majorization techniques, and the expectation-maximization algorithm: a refresher , 2004, IEEE Signal Process. Mag..

[11]  J. Pernier,et al.  Stimulus Specificity of Phase-Locked and Non-Phase-Locked 40 Hz Visual Responses in Human , 1996, The Journal of Neuroscience.

[12]  E. Vaadia,et al.  Spatiotemporal firing patterns in the frontal cortex of behaving monkeys. , 1993, Journal of neurophysiology.

[13]  Jonathan D. Victor,et al.  Metric-space analysis of spike trains: theory, algorithms and application , 1998, q-bio/0309031.

[14]  W. Singer Consciousness and the Binding Problem , 2001, Annals of the New York Academy of Sciences.

[15]  H. Matsuda Cerebral blood flow and metabolic abnormalities in Alzheimer’s disease , 2001, Annals of nuclear medicine.