From neural development to cognition: unexpected roles for chromatin

[1]  Jonathan R. Pollack,et al.  The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers , 2013, PloS one.

[2]  C. Roberts,et al.  ARID1A mutations in cancer: another epigenetic tumor suppressor? , 2013, Cancer discovery.

[3]  Bradley P. Coe,et al.  Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders , 2012, Science.

[4]  J. Yates,et al.  HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory , 2012, Cell.

[5]  Data production leads,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[6]  O. Abdel-Wahab,et al.  The role of mutations in epigenetic regulators in myeloid malignancies , 2012, Nature Reviews Cancer.

[7]  R. Zannolli,et al.  Corpus callosum abnormalities, intellectual disability, speech impairment, and autism in patients with haploinsufficiency of ARID1B , 2012, Clinical genetics.

[8]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[9]  M. Simpson,et al.  De novo mutations in MLL cause Wiedemann-Steiner syndrome. , 2012, American journal of human genetics.

[10]  Mi-Sung Kim,et al.  An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation , 2012, The Journal of Neuroscience.

[11]  C. Yardin,et al.  Dose dependent expression of HDAC4 causes variable expressivity in a novel inherited case of brachydactyly mental retardation syndrome , 2012, American journal of medical genetics. Part A.

[12]  S. Akbarian,et al.  Epigenetic mechanisms in neurological disease , 2012, Nature Medicine.

[13]  Christian Gilissen,et al.  Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. , 2012, American journal of human genetics.

[14]  L. Shaffer,et al.  Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. , 2012, American journal of human genetics.

[15]  G. Crabtree,et al.  Dynamics and Memory of Heterochromatin in Living Cells , 2012, Cell.

[16]  Peter A. Jones.  Functions of DNA methylation: islands, start sites, gene bodies and beyond , 2012, Nature Reviews Genetics.

[17]  Toshiro K. Ohsumi,et al.  Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries , 2012, Cell.

[18]  Michael F. Walker,et al.  De novo mutations revealed by whole-exome sequencing are strongly associated with autism , 2012, Nature.

[19]  Evan T. Geller,et al.  Patterns and rates of exonic de novo mutations in autism spectrum disorders , 2012, Nature.

[20]  F. Gage,et al.  Modeling psychiatric disorders at the cellular and network levels , 2012, Molecular Psychiatry.

[21]  Christian Gilissen,et al.  Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndrome , 2012, Nature Genetics.

[22]  Yves Moreau,et al.  Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome , 2012, Nature Genetics.

[23]  Tadashi Kaname,et al.  New from NPG , 2012, Nature Medicine.

[24]  E. Schröck,et al.  Haploinsufficiency of ARID1B, a member of the SWI/SNF-a chromatin-remodeling complex, is a frequent cause of intellectual disability. , 2012, American journal of human genetics.

[25]  Mark F Bear,et al.  Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. , 2012, Cold Spring Harbor perspectives in biology.

[26]  Bradley P. Coe,et al.  Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations , 2012, Nature.

[27]  H. Sawa,et al.  Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development. , 2012, Developmental biology.

[28]  Steven J. M. Jones,et al.  Mutations in EZH2 cause Weaver syndrome. , 2012, American journal of human genetics.

[29]  Histone modification defects in developmental disorders and cancer , 2012, Oncotarget.

[30]  Martin Renqiang Min,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[31]  A. Reis,et al.  In-Frame Deletion and Missense Mutations of the C-Terminal Helicase Domain of SMARCA2 in Three Patients with Nicolaides-Baraitser Syndrome , 2012, Molecular Syndromology.

[32]  D. Surmeier,et al.  Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. , 2011, Nature.

[33]  Katrina Tatton-Brown,et al.  Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height , 2011, Oncotarget.

[34]  Keiichi I. Nakayama,et al.  Histone H1 Recruitment by CHD8 Is Essential for Suppression of the Wnt–β-Catenin Signaling Pathway , 2011, Molecular and Cellular Biology.

[35]  J. Clayton-Smith,et al.  Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome. , 2011, American journal of human genetics.

[36]  Hans van Bokhoven,et al.  Genetic and epigenetic networks in intellectual disabilities. , 2011, Annual review of genetics.

[37]  Fred H. Gage,et al.  Modelling schizophrenia using human induced pluripotent stem cells , 2011, Nature.

[38]  Wei Chen,et al.  Deep sequencing reveals 50 novel genes for recessive cognitive disorders , 2011, Nature.

[39]  Steven Henikoff,et al.  Histone modification: cause or cog? , 2011, Trends in genetics : TIG.

[40]  Arnold Munnich,et al.  MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression , 2011, Science.

[41]  Maria Teresa Dell'Anno,et al.  Direct generation of functional dopaminergic neurons from mouse and human fibroblasts , 2011, Nature.

[42]  Li Li,et al.  MicroRNA-mediated conversion of human fibroblasts to neurons , 2011, Nature.

[43]  D. Patel,et al.  ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. , 2011, Nature structural & molecular biology.

[44]  J. Shendure,et al.  Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome , 2011, American journal of medical genetics. Part A.

[45]  J. David Sweatt,et al.  Epigenetic Mechanisms in Cognition , 2011, Neuron.

[46]  Raja Jothi,et al.  esBAF Facilitates Pluripotency by Conditioning the Genome for LIF/STAT3Signalingand by Regulating Polycomb Function , 2011, Nature Cell Biology.

[47]  G. Crabtree,et al.  ATP-dependent chromatin remodeling: genetics, genomics and mechanisms , 2011, Cell Research.

[48]  T. Deerinck,et al.  Investigating synapse formation and function using human pluripotent stem cell-derived neurons , 2011, Proceedings of the National Academy of Sciences.

[49]  L. Luo,et al.  The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting , 2011, Neural Development.

[50]  K. Devriendt,et al.  A Balanced Translocation t(6;14)(q25.3;q13.2) Leading to Reciprocal Fusion Transcripts in a Patient with Intellectual Disability and Agenesis of Corpus Callosum , 2010, Cytogenetic and Genome Research.

[51]  Scott L Pomeroy,et al.  Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. , 2010, Cancer cell.

[52]  Richard A. Moore,et al.  ARID1A mutations in endometriosis-associated ovarian carcinomas. , 2010, The New England journal of medicine.

[53]  A. Tarakhovsky,et al.  Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex , 2010, Proceedings of the National Academy of Sciences.

[54]  Stephen R. Williams,et al.  Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems. , 2010, American journal of human genetics.

[55]  Emily H Turner,et al.  Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome , 2010, Nature Genetics.

[56]  S. Imbeaud,et al.  SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. , 2010, Human molecular genetics.

[57]  R. Xi,et al.  Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. , 2010, Genes & development.

[58]  D. Molfese,et al.  Histone Methylation Regulates Memory Formation , 2010, The Journal of Neuroscience.

[59]  G. Crabtree,et al.  Chromatin remodelling during development , 2010, Nature.

[60]  D. Reinberg,et al.  Role of the polycomb protein EED in the propagation of repressive histone marks , 2009, Nature.

[61]  M. Vidal,et al.  Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition , 2009, Neuron.

[62]  Dustin E. Schones,et al.  Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes , 2009, Cell.

[63]  K. Svoboda,et al.  Experience-dependent structural synaptic plasticity in the mammalian brain , 2009, Nature Reviews Neuroscience.

[64]  M. Itokawa,et al.  Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. , 2009, Human molecular genetics.

[65]  S. Haggarty,et al.  HDAC2 negatively regulates memory formation and synaptic plasticity , 2009, Nature.

[66]  G. Crabtree,et al.  ATP-dependent chromatin remodeling in neural development , 2009, Current Opinion in Neurobiology.

[67]  Alexey I Nesvizhskii,et al.  An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency , 2009, Proceedings of the National Academy of Sciences.

[68]  K. Nakayama,et al.  CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis , 2009, Nature Cell Biology.

[69]  H. van Bokhoven,et al.  Genetic and epigenetic defects in mental retardation. , 2009, The international journal of biochemistry & cell biology.

[70]  G. Crabtree,et al.  MicroRNA-mediated switching of chromatin-remodelling complexes in neural development , 2009, Nature.

[71]  Steven W. Flavell,et al.  Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection , 2008, Neuron.

[72]  M. Mehler.  Epigenetics and the nervous system , 2008, Annals of neurology.

[73]  Juri Rappsilber,et al.  A model for transmission of the H3K27me3 epigenetic mark , 2008, Nature Cell Biology.

[74]  H. Zoghbi,et al.  Failure of neuronal homeostasis results in common neuropsychiatric phenotypes , 2008, Nature.

[75]  A. Battaglia,et al.  Genetic disorders associated with macrocephaly , 2008, American journal of medical genetics. Part A.

[76]  T. Mikkelsen,et al.  Genome-scale DNA methylation maps of pluripotent and differentiated cells , 2008, Nature.

[77]  Terry Magnuson,et al.  Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency , 2008, Stem cells.

[78]  Brandi A. Thompson,et al.  CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes , 2008, Molecular and Cellular Biology.

[79]  Peter Marynen,et al.  Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation. , 2008, American journal of human genetics.

[80]  U. Koch,et al.  Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases , 2007, Proceedings of the National Academy of Sciences.

[81]  I. Graef,et al.  Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes , 2007, Neuron.

[82]  Hidenori Nakajima,et al.  [A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[83]  M. Scott,et al.  ISWI Regulates Higher-Order Chromatin Structure and Histone H1 Assembly In Vivo , 2007, PLoS biology.

[84]  T. Mikkelsen,et al.  Genome-wide maps of chromatin state in pluripotent and lineage-committed cells , 2007, Nature.

[85]  A. Koivisto,et al.  Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate , 2007, Clinical genetics.

[86]  R. Aebersold,et al.  An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development , 2007, Neuron.

[87]  M. Stratton,et al.  The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene , 2007, Journal of Medical Genetics.

[88]  Joel M Stein,et al.  Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation , 2007, The Journal of Neuroscience.

[89]  J. Opitz,et al.  A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome , 2007, Nature Genetics.

[90]  N. Belyaev,et al.  BRG1 Chromatin Remodeling Activity Is Required for Efficient Chromatin Binding by Repressor Element 1-silencing Transcription Factor (REST) and Facilitates REST-mediated Repression* , 2006, Journal of Biological Chemistry.

[91]  R. Moon,et al.  The ups and downs of Wnt signaling in prevalent neurological disorders , 2006, Oncogene.

[92]  Alex Magee,et al.  Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome. , 2006, American journal of human genetics.

[93]  H. Zoghbi,et al.  MeCP2 dysfunction in Rett syndrome and related disorders. , 2006, Current opinion in genetics & development.

[94]  J. Zeitlinger,et al.  Polycomb complexes repress developmental regulators in murine embryonic stem cells , 2006, Nature.

[95]  Michael D. Kim,et al.  Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. , 2006, Genes & development.

[96]  T. Yao,et al.  Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death , 2005, The Journal of Neuroscience.

[97]  C. Schwartz,et al.  Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate , 2005, Journal of Medical Genetics.

[98]  Johan T den Dunnen,et al.  Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. , 2005, American journal of human genetics.

[99]  L. Sommer,et al.  Wnt signaling: multiple functions in neural development , 2005, Cellular and Molecular Life Sciences CMLS.

[100]  J. Gécz,et al.  Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. , 2005, American journal of human genetics.

[101]  J. David Sweatt,et al.  Epigenetic mechanisms in memory formation , 2005, Nature Reviews Neuroscience.

[102]  A. Bonni,et al.  brawn for brains: the role of MEF2 proteins in the developing nervous system. , 2005, Current topics in developmental biology.

[103]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[104]  R. Kingston,et al.  Chromatin Compaction by a Polycomb Group Protein Complex , 2004, Science.

[105]  Han G Brunner,et al.  Mutations in a new member of the chromodomain gene family cause CHARGE syndrome , 2004, Nature Genetics.

[106]  M. Mayford,et al.  CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation , 2004, Neuron.

[107]  Peter A. Jones,et al.  Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.

[108]  H. Zoghbi.  Postnatal Neurodevelopmental Disorders: Meeting at the Synapse? , 2003, Science.

[109]  G. Zhu,et al.  Functional Characterization of an Amino-terminal Region of HDAC4 That Possesses MEF2 Binding and Transcriptional Repressive Activity* , 2003, Journal of Biological Chemistry.

[110]  M. Cohen.  Mental deficiency, alterations in performance, and CNS abnormalities in Overgrowth syndromes , 2003, American journal of medical genetics. Part C, Seminars in medical genetics.

[111]  Dimitris Thanos,et al.  Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure , 2002, Cell.

[112]  E. Olson,et al.  Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation , 2002, Molecular and Cellular Biology.

[113]  Anjen Chenn,et al.  Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors , 2002, Science.

[114]  Keesook Lee,et al.  Srg3, a Mouse Homolog of Yeast SWI3, Is Essential for Early Embryogenesis and Involved in Brain Development , 2001, Molecular and Cellular Biology.

[115]  H Clevers,et al.  The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation , 2001, The EMBO journal.

[116]  Xiang-Jiao Yang,et al.  Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and Export Signals , 2001, Molecular and Cellular Biology.

[117]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[118]  M. Surani,et al.  The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development , 2001, Molecular and Cellular Biology.

[119]  A. McMahon,et al.  Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. , 2001, Development.

[120]  坂本 郁夫.  A novel β-catenin-binding protein inhibits β-catenin-dependent Tcf activation and axis formation , 2001 .

[121]  F Randazzo,et al.  A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. , 2000, Molecular cell.

[122]  M. Yaniv,et al.  The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression , 2000, EMBO reports.

[123]  H. Okano,et al.  Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. , 2000, Molecular cell.

[124]  C. Wylie,et al.  Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. , 2000, Developmental biology.

[125]  O. Gwon,et al.  A Balanced Translocation t (2:18) (p23:q23) in the Family. , 2000 .

[126]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[127]  Jay N. Giedd,et al.  Brain Development, IX , 1999 .

[128]  Raoul C. M. Hennekam,et al.  Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP , 1995, Nature.

[129]  Thomas C. Kaufman,et al.  brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2 SWI2 , 1992, Cell.