Adaptive Model Control Applied to Real-Time Blood-Pressure Regulation

A real-time computer-control system for regulating the blood pressure of an animal in a prolonged state of shock has been successfully developed and is being theoretically analyzed. The computer controls the rate of infusion of a vaso-constrictor drug inputed to the animal, and monitors the blood-pressure output. An adaptive model of the animal’s drug response is used to derive the required input for control of future blood-pressure values. A transversal-filter model is used, and control is derived by forward-time calculation including the known internal states of the model.