C. Cotman

C. Cotman, W. V. Van Nostrand, D. Cribbs, 1999, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome

C. Cotman, E. Head, D. Cribbs, 2002, Neuroscience Letters.

Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain

C. Cotman, E. Head, Joseph H. Su, 2002, Acta Neuropathologica.

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

C. Cotman, R. Rissman, E. Head, 2002, Neurobiology of Disease.

Internal States of the Body: Autonomic, Neuroendocrine and Pain Functions

C. Cotman, J. Mcgaugh, J. McGaugh, 1980 .

A machine vision system for the automated classification and counting of neurons in 3-D brain tissue samples

Glenn Healey, William Rodman Shankle, Phillip C.-Y. Sheu, 1996, Proceedings Third IEEE Workshop on Applications of Computer Vision. WACV'96.

What are the earlier life contributions to reserve and resilience?

Stuart J. Ritchie, C. Cotman, K. Walhovd, 2019, Neurobiology of Aging.

Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors

G. Lynch, C. Cotman, P. Vanderklish, 1991, Neuroscience Letters.

β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats

C. Cotman, M. Murphy, E. Head, 2005, Neurobiology of Aging.

Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons.

C. Cotman, C. Pike, J. Watt, 1994, Brain research.

Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

C. Cotman, C. Pike, D. Cunningham, 1997, The Journal of Neuroscience.

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

N. Fox, C. Cotman, J. Grafman, 2014, Acta Neuropathologica.

Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress

C. Cotman, N. Berchtold, Nicole C. Berchtold, 2022, Frontiers in Aging.

Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs

C. Cotman, S. Lowry, N. Milgram, 2004, Experimental Gerontology.

Exercise and brain neurotrophins

C. Cotman, F. Gomez-Pinilla, S. Neeper, 1995, Nature.

Exercise-induced gene expression changes in the rat spinal cord.

C. Cotman, V. Perreau, P. Adlard, 2005, Gene expression.

Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease

C. Cotman, A. Anderson, H. Qian, 2000 .

Possible Coordinated Gene Expressions for FGF Receptor, FGF-5, and FGF-2 Following Seizures

C. Cotman, F. Gomez-Pinilla, E. A. V. D. Wal, 1995, Experimental Neurology.

Exercise and time-dependent benefits to learning and memory

C. Cotman, N. Berchtold, N. Castello, 2010, Neuroscience.

Exercise builds brain health: key roles of growth factor cascades and inflammation

Carl W. Cotman, C. Cotman, N. Berchtold, 2007, Trends in Neurosciences.

Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain

C. Cotman, D. Monaghan, J. Neale, 1986, Neuroscience Letters.

Analysis of brain injury following intrahippocampal administration of β-amyloid in streptozotocin-treated rats

Brian J Cummings, C. Cotman, M. Smyth, 1994, Neurobiology of Aging.

Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons

C. Cotman, D. Loo, E. R. Whittemore, 1994, Neuroreport.

Arrangement of the Acetylcholine Receptor Subunits in the Resting and Desensitized States , Determined by Cryoelectron Microscopy of Crystallized Torpedo Postsynaptic Membranes

C. Cotman, 2002 .

The Cell surface and neuronal function

C. Cotman, G. Nicolson, G. Poste, 1980 .

Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.

C. Cotman, E. R. Lewis, S. Skaper, 1982, Science.

Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione.

C. Cotman, J. Koh, R. Bridges, 1991, European journal of pharmacology.

Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.

A. Ganong, C. Cotman, 1986, The Journal of pharmacology and experimental therapeutics.

Postnatal development of the serotonin innervation of the hippocampus and dentate gyrus following raphe implants

C. Cotman, V. Holets, 1984, The Journal of comparative neurology.

Transplantation of septal neurons maintained in long-term culture

C. Cotman, S. Pixley, R. Gibbs, 1986, Brain Research.

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

C. Cotman, M. Nieto‐Sampedro, G. Barbin, 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity

C. Cotman, E. R. Lewis, S. Skaper, 1983, Brain Research.

Gene expression of Alzheimer‐associated presenilin‐2 in the frontal cortex of Alzheimer and aged control brain

C. Cotman, Joseph H. Su, Gangmin Deng, 1996, FEBS letters.

Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites.

Brian J Cummings, C. Cotman, B. Cummings, 1994, Neuroreport.

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

C. Cotman, D. Araujo, 1993, Brain Research.

Ultrastructural evidence of fibrillar β-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains

C. Cotman, O. Ottersen, N. Milgram, 2000, Neuroscience.

APOPTOSIS IN ALZHEIMER'S DISEASE Inductive Agents and Antioxidant Protective Factors

C. Cotman, C. Pike, 1998 .

Apoptosis in Alzheimer’s Disease

C. Cotman, C. Pike, 1998 .

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: relationship to performance on the Morris water maze.

C. Cotman, A. S. Clark, K. Magnusson, 1992, Behavioral neuroscience.

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

B. Ames, C. Cotman, Zhongbo Liu, 2007, Investigative ophthalmology & visual science.

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine

C. Cotman, N. Milgram, S. Snigdha, 2016, Neurobiology of Aging.

R-α-Lipoic acid and acetyl-l-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes

C. Cotman, L. Packer, K. Liu, 2007, Diabetologia.

The Presence of Isoaspartic Acid in β-Amyloid Plaques Indicates Plaque Age

C. Cotman, E. Head, M. Fonseca, 1999, Experimental Neurology.

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

Carl W. Cotman, D. Allan Butterfield, Bruce A. Muggenburg, 2008, Neurobiology of Aging.

Short-term supplementation with acetyl-l-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles

C. Cotman, W. Opii, N. Milgram, 2009, Experimental Gerontology.

Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging

C. Cotman, E. Head, P. Sullivan, 2009, Experimental Neurology.

Region-specific age at onset of beta-amyloid in dogs.

C. Cotman, N. Milgram, F. Hahn, 2000, Neurobiology of aging.

Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging - eScholarship

C. Cotman, M. Su, N. Milgram, 2004 .

Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

C. Cotman, N. Milgram, E. Head, 1998, Neurobiology of aging.

Bcl-2 family protein behavior in frontotemporal dementia implies vascular involvement

C. Cotman, R. Kim, K. Nichol, 2001, Neurology.

Comparison of the Effects of l‐Carnitine and Acetyl‐l‐Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats

B. Ames, C. Cotman, E. Head, 2004, Annals of the New York Academy of Sciences.

β-Amyloid Increases Enzyme Activity and Protein Levels of Glutamine Synthetase in Cultured Astrocytes

C. Cotman, C. Pike, Stephan S. Miller, 1996, Experimental Neurology.

Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease.

C. Cotman, D. Araujo, 1992, Brain research.

Up‐regulation of Bcl‐2 is associated with neuronal DNA damage in Alzheimer's disease

C. Cotman, A. Anderson, Joseph H. Su, 1996, NeuroReport.

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology.

Brian J Cummings, C. Cotman, C. Pike, 1992, Neuroreport.

Hypertrophy and redistribution of astrocytes in the deafferented dentate gyrus

G. Lynch, G. Rose, C. Cotman, 1976, Brain Research Bulletin.

Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning.

C. Cotman, C. Finch, J. Geddes, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Hydrocortisone administration retards axon sprouting in the rat dentate gyrus

C. Cotman, S. Scheff, L. Benardo, 1980, Experimental Neurology.

Invertebrate Learning and Memory

Carl W. Cotman, Bernard W. Agranoff, Michael D. Uhler, 1999 .

The Development of Behavior

Carl W. Cotman, James L. McGaugh, C. Cotman, 2022 .

High ciliary neuronotrophic specific activity in rat peripheral nerve

C. Cotman, M. Nieto‐Sampedro, M. Manthorpe, 1984, International Journal of Developmental Neuroscience.

Hydrocortison administration retards axon sprouting in the rat dentate gyrus.

C. Cotman, S. Scheff, L. Benardo, 1980, Experimental neurology.

Differential effects of interleukin-1β and interleukin-2 on glia and hippocampal neurons in culture

C. Cotman, D. Araujo, 1995, International Journal of Developmental Neuroscience.

A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain

C. Cotman, D. Monaghan, R. Bridges, 1986, Brain Research.

A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: l-anti-endo-3,4-methanopyrrolidine dicarboxylate

C. Cotman, R. Bridges, F. Lovering, 1994, Neuroscience Letters.

Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions: II. Effects of partial entorhinal and simultaneous multiple lesions

G. Lynch, C. Cotman, J. Nadler, 1977, The Journal of comparative neurology.

Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells

C. Cotman, C. Pike, Gangmin Deng, 1996, FEBS letters.

BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p38 MAPK

C. Cotman, D. Cribbs, E. Kramár, 2013 .

Title: Frontal Lobe Volume, Function, and A (cid:1) Pathology in a Canine Model of Aging Abbreviated Title: Frontal Lobe Volume and Aging in the Beagle

C. Cotman, E. Head, F. Gao, 2005 .

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.

Brian J Cummings, C. Cotman, R. Shankle, 1996, Neurobiology of aging.

Deposition of phosphorylated amyloid‐β in brains of aged nonhuman primates and canines

C. Cotman, R. Palmour, C. Lemere, 2018, Brain pathology.

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

C. Cotman, V. Vasilevko, D. Cribbs, 2003, International immunology.

Adjuvant-dependent modulation of T h 1 and T h 2 responses to immunization with b-amyloid

C. Cotman, V. Vasilevko, D. Cribbs, 2003 .

Title An amyloid β 42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer ' s disease Permalink

C. Cotman, D. Piomelli, G. Astarita, 2012 .

Amyloid βprotein precursor in cultured leptomeningeal smooth muscle cells

C. Cotman, A. Rozemuller, S. Saporito-irwin, 1994 .

Membrane linked proteins at CNS synapses

P. Kelly, C. Cotman, R. Liem, 1977, Brain Research.

Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells

C. Cotman, W. V. Van Nostrand, J. Davis-Salinas, 1995 .

Gliotoxic actions of excitatory amino acids

Brian J Cummings, C. Cotman, R. Bridges, 1992, Neuropharmacology.

1‐Aminocyclopentane‐trans‐1,3‐Dicarboxylic Acid Induces Glutamine Synthetase Activity in Cultured Astrocytes

C. Cotman, R. Bridges, S. Miller, 1992, Journal of neurochemistry.

Voltage‐gated currents expressed by rat microglia in culture

C. Cotman, A. Korotzer, Andrew R. Korotzer, 1992, Glia.

Hippocampal but not astrocyte transplants enhance recovery on a forced choice alternation task after kainate lesions

C. Cotman, J. Kesslak, M. Nieto‐Sampedro, 1988, Brain Research.

Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes

C. Cotman, M. Nieto‐Sampedro, S. Pixley, 1987, Journal of neuroscience research.

Laminin supports short‐term survival of rat septal neurons in low‐density, serum‐free cultures

C. Cotman, S. Pixley, S. K. R. Pixley, 1986, Journal of neuroscience research.

Low‐Dose Propranolol Reduces Aggression and Agitation Resembling That Associated with Orbitofrontal Dysfunction in Elderly Demented Patients

C. Cotman, K. Nielson, W. Shankle, 1995, Alzheimer disease and associated disorders.

Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered.

C. Cotman, M. Hennerici, R. Zerfass, 1998, Journal of neural transmission. Supplementum.

PET studies of hippocampal metabolism in patients with Alzheimer's disease during an olfactory memory task

G. Lynch, C. Cotman, M. Buchsbaum, 1989 .

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

Brian J Cummings, C. Cotman, K. Nielson, 1996, Brain Research.

Identification of myosin in isolated synaptic junctions

P. Kelly, C. Cotman, J. A. Babitch, 1981, Brain Research.

Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?

C. Cotman, I. Soltesz, M. Schachner, 1998, Progress in Neurobiology.

The β-Amyloid Model of Alzheimer's Disease:Conformation Change, Receptor Cross-Linking, the Initiation of Apoptosis

C. Cotman, A. Anderson, D. Cribbs, 1996 .

Neurotrophic activity in the central and peripheral nervous systems of the cat. Effects of injury

C. Cotman, M. Nieto‐Sampedro, Jen Yu, 1986, Brain Research.

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

C. Cotman, P. Vaughan, Joseph H. Su, 1994, Brain Research.

BDNF and Alzheimer's Disease—What's the Connection?

C. Cotman, N. Berchtold, 2003 .

Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with The

C. Cotman, D. Salmon, H. Feldman, 2020 .

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

C. Cotman, T. Rohn, K. J. Ivins, 1999, Neurobiology of disease.

Effects of entorhinal lesions on trophic activities present in rat entorhinal cortex and hippocampus as studied using primary cultures of entorhinal and septal tissues

C. Cotman, R. Gibbs, D. L. Needels, 1987, Journal of neuroscience research.

Adult and embryonic frontal cortex transplants after frontal cortex ablation enhance recovery on a reinforced alternation task

C. Cotman, J. Kesslak, L. Brown, 1986, Experimental Neurology.

Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex

C. Cotman, F. Gomez-Pinilla, Fernando Gomez-Pinilla, 1992, Neuroscience.

Achieving and maintaining cognitive vitality with aging.

Arthur F Kramer, Tim Tully, Lewis H Kuller, 2002, Mayo Clinic proceedings.

Long-term support by injured brain extract of a subpopulation of ciliary ganglion neurons purified by differential adhesion

C. Cotman, M. Nieto‐Sampedro, D. L. Needels, 1987, Neurochemical Research.

A simple, objective method to measure the activity of factors that promote neuronal survival

C. Cotman, M. Nieto‐Sampedro, D. L. Needels, 1985, Journal of Neuroscience Methods.

Differentiation of serum‐free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity

C. Cotman, D. Loo, M. Althoen, 1995, Journal of neuroscience research.

Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion

C. Cotman, R. Bridges, K. Anderson, 1991, Brain Research.

Canine cognition, aging and neuropathology

C. Cotman, N. Milgram, E. Head, 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Canine cognition, aging and neuropathology. Introduction.

C. Cotman, N. Milgram, E. Head, 2000, Progress in neuro-psychopharmacology & biological psychiatry.

Molecular weights of the polypeptide chains of synaptic plasma membranes.

C. Cotman, G. Banker, B. Crain, 1972, Brain research.

ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN

W. Levy, C. Cotman, J. Haycock, 1976, British journal of pharmacology.

Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome.

C. Cotman, C. Glabe, E. Head, 2001, Neurobiology of disease.

In Reply: Non-Insulin-Dependent Diabetes Mellitus and Alzheimer's Disease

C. Cotman, K. Nielson, R. Mulnard, 1997 .

Analysis of myelin-synaptosomal interactions in sucrose and Ficoll-sucrose gradients.

C. Cotman, L. Doyle, 1972, Analytical biochemistry.

Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine

B. Ames, C. Cotman, F. Gao, 2009, Neurochemical Research.

Cooperation between nerve growth factor and laminin or fibronectin in promoting sensory neuron survival and neurite outgrowth.

C. Cotman, M. Nieto‐Sampedro, A. Millaruelo, 1988, Brain research.

Behavioral Neuroscience: An Introduction

C. Cotman, P. Mulvanny, J. Mcgaugh, 2014 .

Glutamate and aspartate binding sites are enriched in synaptic junctions isolated from rat brain

G. Fagg, C. Cotman, A. Foster, 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Resolution of insoluble proteins in rat brain subcellular fractions.

C. Cotman, H. Mahler, 1967, Archives of biochemistry and biophysics.

The identification of membrane glycocomponents in polyacrylamide gels: a rapid method using 125I-labeled lectins.

P. Kelly, C. Cotman, J. Rostas, 1977, Analytical biochemistry.

Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats

C. Cotman, V. Vijayan, 1983, Neurobiology of Aging.

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

Brian J Cummings, C. Cotman, R. Neve, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Principles for the Optimization of Centrifugation Conditions for Fractionation of Brain Tissue

C. Cotman, 1972 .

Metabotropic Glutamate Receptor Agonists Potentiate Cyclic AMP Formation Induced by Forskolin or β‐Adrenergic Receptor Activation in Cerebral Cortical Astrocytes in Culture

R. Balázs, C. Cotman, Stephan S. Miller, 1998, Journal of neurochemistry.

Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease.

Brian J Cummings, C. Cotman, B. Cummings, 1993, Neurobiology of aging.

Open Field Activity and Human Interaction as a Function of Age and Breed in Dogs

Brian J Cummings, C. Cotman, N. Milgram, 1997, Physiology & Behavior.

Calcium, membranes, aging, and Alzheimer's disease

C. Cotman, J. Pettegrew, Z. Khachaturian, 1989 .

Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes.

C. Cotman, D. Loo, M. Althoen, 1994, Neuroreport.

Synapse replacement in the nervous system of adult vertebrates.

C. Cotman, E. Harris, M. Nieto‐Sampedro, 1981, Physiological reviews.

The role of trophic factors in behavioral recovery and integration of transplants.

C. Cotman, J. Kesslak, 1988, Progress in brain research.

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

C. Cotman, M. Nieto‐Sampedro, R. Lim, 1988, Neuroscience Letters.

Apolipoprotein‐E Genotyping of Diabetic Dementia Patients: Is Diabetes Rare in Alzheimer's Disease?

C. Cotman, K. Nielson, R. Mulnard, 1996, Journal of the American Geriatrics Society.

Enhanced stimulus-secretion coupling from brains of aged mice

J. D. McGaugh, C. Cotman, J. Haycock, 1977, Experimental Neurology.

Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus

C. Cotman, D. Monaghan, R. Wenthold, 1985, Brain Research.

Factors affecting innervation in the CNS: comparison of three cholinergic cell types transplanted to the hippocampus of adult rats

C. Cotman, R. Gibbs, K. Anderson, 1986, Brain Research.

Characteristics of different amino acids as protein precursors in mouse brain: advantages of certain carboxyl-labeled amino acids.

C. Cotman, G. Banker, 1971, Archives of biochemistry and biophysics.

L-glutamate and l-aspartate bind to separate sites in rat brain synaptic membranes

G. Fagg, C. Cotman, A. Foster, 1981, Brain Research.

N-Methyl-d-aspartate promotes the survival of cerebellar granule cells: Pharmacological characterization

R. Balázs, C. Cotman, O. Jørgensen, 1989, Neuroscience Letters.

NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons

C. Cotman, G. Brewer, Carl W. Cotman, 1989, Neuroscience Letters.

The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

C. Cotman, D. Monaghan, 1982, Brain Research.

Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease.

Brian J Cummings, C. Cotman, C. Pike, 1994, Neuroscience.

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

Carl W. Cotman, Dennis D. Cunningham, C. Cotman, 1989, Nature.

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

Gregory J. Brewer, Carl W. Cotman, C. Cotman, 1989, Brain Research.

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

C. Cotman, D. Monaghan, D. Toy, 1983, Nature.

Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year.

C. Cotman, D. Galasko, B. Reed, 2013, Archives of gerontology and geriatrics.

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

C. Cotman, A. Anderson, 1995, Molecular Neurobiology.

Loss and reacquisition of hippocampal synapses after selective destruction of CA3–CA4 afferents with kainic acid

C. Cotman, J. Nadler, C. Gentry, 1980, Brain Research.

Glutamate as transmitter of hippocampal perforant path

A. Hamberger, C. Cotman, J. Nadler, 1977, Nature.

5. Molecular dating of senile plaques in the brains of individuals with Down syndrome.

C. Cotman, E. Head, R. Torp, 2000 .

Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain

C. Cotman, F. Gomez-Pinilla, E. A. V. D. Wal, 1994, Neuroscience.

The P-Amyloid Peptide, Peptide Self-Assembly, and the Emergence

C. Cotman, 2006 .

The β‐Amyloid Peptide, Peptide Self‐Assembly, and the Emergence of Biological Activities

C. Cotman, 1997 .

Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury

C. Cotman, V. Perreau, H. Keirstead, 2004, Journal of neuroscience research.

Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord

Carl W. Cotman, A. Ganong, C. Cotman, 1983, Brain Research.

Regional Distribution of α‐[3H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Binding Sites in Rat Brain: Effect of Chemical Modification of SH– Groups in Tissue Sections

C. Altar, C. Cotman, D. Monaghan, 1990, Journal of neurochemistry.

NMDA receptor activation and early olfactory learning.

C. Cotman, E. Harris, M. Leon, 1988, Brain research.

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

C. Cotman, J. Geddes, I. Lott, 1986, Brain Research.

Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

C. Cotman, J. Nadler, C. Gentry, 1980, The Journal of comparative neurology.

Moderate to high-intensity physical exercise in patients with Alzheimer’s disease

C. Cotman, P. Johannsen, G. Waldemar, 2015, Alzheimer's & Dementia.

Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design

C. Cotman, P. Johannsen, G. Waldemar, 2013, Neuroepidemiology.

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

Brian J Cummings, C. Cotman, C. Pike, 1994, Neuroscience.

Amyloid beta protein enhances the survival of hippocampal neurons in vitro.

C. Cotman, D. Selkoe, J. Whitson, 1989, Science.

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

C. Cotman, J. Nadler, J. VICTOR NADLER, 1978, Nature.

Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomes

C. Cotman, M. Sandoval, P. Horch, 1978, Brain Research.

Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents

G. Lynch, C. Cotman, J. Nadler, 1976, Nature.

Excitatory amino acid antagonists depress transmission in hippocampal projections to the lateral septum

C. Cotman, D. Stevens, 1986, Brain Research.

β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised*

R. Balázs, C. Cotman, P. Thornton, 2001, The Journal of Biological Chemistry.

Perforated postsynaptic densities: probable intermediates in synapse turnover.

C. Cotman, M. Nieto‐Sampedro, S. Hoff, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes.

C. Cotman, D. Monaghan, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses

G. Lynch, C. Cotman, N. Berchtold, 2017, The Journal of Neuroscience.

Identification of glycoproteins and proteins at synapses in the central nervous system.

P. Kelly, C. Cotman, 1977, The Journal of biological chemistry.

Attenuation of β‐Amyloid Neurotoxicity In Vitro by Potassium‐Induced Depolarization

R. Balázs, C. Cotman, C. Pike, 1996, Journal of neurochemistry.

Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate‐induced epileptic seizures

R. Balázs, C. Cotman, J. Kesslak, 2000, Glia.

Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes

C. Cotman, C. Romano, C. Cotman, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Roles of Metabotropic Glutamate Receptors in Brain Plasticity and Pathology

C. Cotman, J. Kesslak, C. Romano, 1995, Annals of the New York Academy of Sciences.

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.

C. Cotman, D. Monaghan, E. Palmer, 1989, European journal of pharmacology.

Effects of synaptic antagonists on perforant path paired-pulse plasticity: differentiation of pre- and postsynaptic antagonism

C. Cotman, E. Harris, C. W. Cotman, 1985, Brain Research.

Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat

C. Cotman, D. Stevens, 1991, Brain Research.

2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus

A. Ganong, C. Cotman, T. Lanthorn, 1984, Brain Research.

An analytical micro-method for electron microscopic study of the composition and sedimentation properties of subcellular fractions.

C. Cotman, D. A. Flansburg, D. Flansburg, 1970, Brain research.

Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation.

C. Cotman, F. Snyder, C Cotman, 1969, Biochemistry.

Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization.

C. Cotman, D. A. Matthews, 1971, Biochimica et biophysica acta.

CHARACTERIZATION OF PUTATIVE AMINO ACID TRANSMITTER RELEASE FROM SLICES OF RAT DENTATE GYRUS

C. Cotman, J. Nadler, W. White, 1977, Journal of neurochemistry.

Analytical differential centrifugation: an analysis of the sedimentation properties of synaptosomes, mitochondria and lysosomes from rat brain homogenates.

C. Cotman, N. Anderson, D. Brown, 1970, Archives of biochemistry and biophysics.

Cell biology of synaptic plasticity.

C. Cotman, M. Nieto‐Sampedro, 1984, Science.

Brain function, synapse renewal, and plasticity.

C. Cotman, M. Nieto‐Sampedro, 1982, Annual review of psychology.

Potentiation of the excitatory synaptic action of commissural, associational and entorhinal afferents to dentate granule cells

O. Steward, C. Cotman, W. White, 1977, Brain Research.

Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus

C. Cotman, T. Lanthorn, 1981, Brain Research.

Changes in protein levels in perfusates of freely moving cats: relation to behavioral state.

J. D. McGaugh, C. Cotman, C. Spanis, 1975, Science.

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

Carl W. Cotman, C. Cotman, C. Pike, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Alzheimer's Presenilin-1 Mutation Potentiates Inositol 1,4,5-Trisphosphate-Mediated Calcium Signaling in Xenopus

C. Cotman, F. LaFerla, M. Leissring, 1999 .

Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia

C. Cotman, D. Monaghan, T. Wieloch, 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons.

C. Cotman, J. H. Neal, C. Peterson, 1989, Brain research. Developmental brain research.

Changes in excitatory amino acid modulation of phosphoinositide metabolism during development.

C. Cotman, A. Roxas, J. Krause, 1990, Brain research. Developmental brain research.

GDEE antagonism of iontophoretic amino acid excitations in the intact hippocampus and in the hippocampal slice preparation

G. Lynch, C. Cotman, V. Gribkoff, 1976, Brain Research.

Long lasting changes in the spontaneous activity of hippocampal neurons following stimulation of the entorhinal cortex

G. Lynch, S. Deadwyler, C. Cotman, 1976, Brain Research Bulletin.

Strain-dependent decrease in glutamate binding to the N-methyl-d-aspartic acid receptor during aging

C. Cotman, C. Peterson, 1989, Neuroscience Letters.

Sleep and Activity Rhythms

C. Cotman, J. McGaugh, 1980 .

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

C. Cotman, Erica D. Smith, G. A. Prieto, 2018, Neurochemical Research.

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

C. Cotman, Joseph H. Su, Gangmin Deng, 1997, Brain Research.

The progression of β-amyloid deposition in the frontal cortex of the aged canine

Brian J Cummings, C. Cotman, K. Nielson, 1997, Brain Research.

Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.

C. Cotman, T. Montine, D. Galasko, 2012, Archives of neurology.

Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection

C. Cotman, J. Borg, P. Kesslak, 1990, Brain Research.

Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus

C. Cotman, V. Vijayan, 1987, Experimental Neurology.

Chronic glucocorticoid therapy alters axon sprouting in the hippocampal dentate gyrus

C. Cotman, S. Scheff, 1982, Experimental Neurology.

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

P Woodbury, L. Schneider, C. Cotman, 1997, The New England journal of medicine.

Neurotransmitter characteristics of brain grafts: Striatal and septal tissues form the same laminated input to the hippocampus

C. Cotman, E. R. Lewis, 1983, Neuroscience.

Cross-linking of Concanavalin A receptors on cortical neurons induces programmed cell death

C. Cotman, A. Anderson, D. Cribbs, 1996, Neuroscience.

Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate.

G. Lynch, C. Cotman, T. Chippendale, 1974, Brain research.

Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress

C. Cotman, A. Nordberg, O. Ottersen, 2007, Neurobiology of Disease.

Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment

C. Cotman, Donghou Kim, Joseph H. Su, 1999, Brain Research.

Autoradiographic analysis of protein synthesis in synaptosomal fractions.

C. Cotman, D. Taylor, 1971, Brain research.

Region-specific age at onset of β-amyloid in dogs☆

C. Cotman, N. Milgram, F. Hahn, 2000, Neurobiology of Aging.

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.

C. Cotman, D. Wallace, E. Head, 2010, Journal of Alzheimer's disease : JAD.

Thirst and Hunger

C. Cotman, J. McGaugh, 1980 .

An electromechanical pH stat providing bidirectional control

C. Cotman, D. Smith, 1964 .

Hippocampal Plasticity and Excitatory Neurotransmitters

G. Fagg, C. Cotman, T. Lanthorn, 1982 .

Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density

C. Cotman, S. Scheff, L. Benardo, 1982, The Journal of comparative neurology.

Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response

C. Cotman, S. Scheff, S. Hoff, 1982, The Journal of comparative neurology.

Calcium-dependent γ-aminobutyrate release by interneurons of rat hippocampal regions: Lesion-induced plasticity

C. Cotman, J. Nadler, W. White, 1977, Brain Research.

Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool

A. Hamberger, C. Cotman, G. Chiang, 1979, Brain Research.

An overview of glutamate as a neurotransmitter.

C. Cotman, T. Lanthorn, T Lanthorn, 1981, Advances in biochemical psychopharmacology.

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

C. Cotman, M. Sabbagh, N. Berchtold, 2014, Neurobiology of Aging.

Temporal parameters of axon “sprouting” in the brain of the adult rat

G. Lynch, C. Cotman, C. Gall, 1977, Experimental Neurology.

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

C. Cotman, K. Anderson, D. Dam, 1988, Nature.

Pathologic concentrations of ammonium ions block l-glutamate uptake

C. Cotman, E. Mena, 1985, Experimental Neurology.

Cations differentially affect subpopulations ofl-glutamate receptors in rat synaptic plasma membranes

C. Cotman, D. Monaghan, S. Whittemore, 1985, Brain Research.

EFFECTS OF ELEVATED [K+]0 ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION?

W. Levy, C. Cotman, J. Haycock, 1978, Journal of neurochemistry.

Stimulation-dependent depression of readily releasable neurotransmitter pools in brain

W. Levy, C. Cotman, J. Haycock, 1976, Brain Research.

Anatomical Organization of NMDA, Kainate and Quisqualate Receptors

C. Cotman, D. Monaghan, 1986 .

Pentobarbital depression of stimulus-secretion coupling in brain--selective inhibition of depolarization-induced calcium-dependent release.

W. Levy, C. Cotman, J. Haycock, 1977, Biochemical pharmacology.

The Development, Remodeling and Aging of Neuronal Circuitry

C. Cotman, J. McGaugh, 1980 .

Principles of Neuroanatomy

Carl W. Cotman, Jay B. Angevine, C. Cotman, 1981 .

Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions.

G. Lynch, C. Cotman, D. A. Matthews, 1972, Brain research.

The canine as an animal model of human aging and dementia

Brian J Cummings, C. Cotman, N. Milgram, 1996, Neurobiology of Aging.

Landmark discrimination learning in the dog.

C. Cotman, B. Mackay, N. Milgram, 1999, Learning & memory.

Emergence of artistic talent in frontotemporal dementia

B L Miller, F Prince, K. Boone, 1998, Neurology.

5 – Synaptic Transmission

C. Cotman, J. McGaugh, 1980 .

17 – Behavioral Disorders

C. Cotman, J. McGaugh, 1980 .

Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs

C. Cotman, N. Milgram, L. Christie, 2011, AGE.

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

Brian J Cummings, C. Cotman, T. Satou, 1995, Brain Research.

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

C. Cotman, C. Pike, C. Glabe, 1995 .

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.

C. Cotman, C. Pike, C. Glabe, 1995, Journal of neurochemistry.

Cyclic AMP-stimulated protein kinases at brain synaptic junctions.

P. Kelly, C. Cotman, M. Largen, 1979, The Journal of biological chemistry.

Optimal concentration of iodonitrotetrazolium for the isolation of junctional fractions from rat brain

C. Cotman, M. Nieto‐Sampedro, C. Bussineau, 1981, Neurochemical Research.

Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging

C. Cotman, W. Brooks, O. Nalcioglu, 1998, Neurobiology of Aging.

Insoluble Proteins of the Synaptic Plasma Membrane

C. Cotman, H. Mahler, 1970 .

Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons

C. Cotman, D. Stevens, 1987, Neuroscience Letters.

Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata

C. Cotman, J. Nadler, D. Shelton, 1979, Brain Research.

Excitatory Amino Acids and Hepatic Encephalopathy

C. Cotman, R. Butterworth, J. Szerb, 1989 .

Chloride ions enhance L-glutamate binding to rat brain synaptic membranes

G. Fagg, C. Cotman, E. Mena, 1982, Brain Research.

ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN

C. Cotman, Dwan A. Taylor, 1972, The Journal of cell biology.

BIOCHEMICAL CORRELATES OF TRANSMISSION MEDIATED BY GLUTAMATE AND ASPARTATE

C. Cotman, J. Nadler, K. Vaca, 1978, Journal of neurochemistry.

Glutamate as a CNS Neurotransmitter: Properties of Release, Inactivation and Biosynthesis

A. Hamberger, C. Cotman, 1978 .

Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate

A. Hamberger, C. Cotman, S. Scheff, 1979, Brain Research.

Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus

A. Hamberger, C. Cotman, J. Cummins, 1978, Brain Research.

Stimulus secretion coupling in vitro: a rapid perfusion apparatus for monitoring efflux of transmitter substances from tissue samples.

J. Biela, C. Cotman, D. Redburn, 1975, Analytical biochemistry.

CALCIUM‐DEPENDENT RELEASE OF EXOGENOUSLY LOADED γ‐AMINO‐[U‐14C]BUTYRATE FROM SYNAPTOSOMES: TIME COURSE OF STIMULATION BY POTASSIUM, VERATRIDINE, AND THE CALCIUM IONOPHORE, A23187

C. Cotman, D. Redburn, D. Shelton, 1976, Journal of neurochemistry.

Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.

C. Cotman, J. Haycock, W. White, 1976, The Journal of physiology.

Action of 3-((±)-2-car☐ypiperazin-4-yl)-propyl-1-phosphonic aci (CPP): a new and highly potent antagonist of N-methyl-d-aspartate receptors in the hippocampus

A. Ganong, C. Cotman, D. Monaghan, 1986, Brain Research.

Parallel antagonism of synaptic transmission and kainate/quisqualate responses in the hippocampus by piperazine-2,3-dicarboxylic acid analogs

A. Ganong, C. Cotman, J. Watkins, 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Microfluidic Multicompartment Device for Neuroscience Research.

Noo Li Jeon, C. Cotman, N. Jeon, 2003, Langmuir : the ACS journal of surfaces and colloids.

Increased sensitivity to adenosine in the rat dentate gyrus molecular layer two weeks after partial entorhinal lesions

C. Cotman, J. Kahle, J. Ulłas, 1993, Brain Research.

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

C. Cotman, M. Cahalan, L. Thompson, 2020, Nature Communications.

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

R. Balázs, C. Cotman, W. Thangnipon, 2008, Neurobiology of Aging.

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy*

O. Steward, C. Cotman, Erica D. Smith, 2014, The Journal of Biological Chemistry.

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

Carl W. Cotman, C. Cotman, Karlie A. Intlekofer, 2013, Neurobiology of Disease.

Specific binding of kainic acid to purified subcellular fractions from rat brain

C. Cotman, M. Nieto‐Sampedro, D. Shelton, 1980, Neurochemical Research.

Presenilins and Alzheimer’s Disease

Brian, Stanley, Anderton, 1998, Research and Perspectives in Alzheimer’s Disease.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sonja W. Scholz, W. M. van der Flier, Till F. M. Andlauer, 2019, Acta Neuropathologica.

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Carl W. Cotman, Joseph Rogers, Paul D. Coleman, 2013, Neurobiology of Aging.

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Michelle K. Lupton, D. Geschwind, J. Haines, 2012, Human molecular genetics.

Biochemical correlates of respiratory deficiency. VII. Glucose repression.

C. Cotman, H. Mahler, J. Jayaraman, 1966, Archives of biochemistry and biophysics.

Neurobiology of Exercise

Barry E. Levin, V. Edgerton, S. Gandevia, 2006 .

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes

C. Cotman, N. Berchtold, Z. Liposits, 2012, Journal of Neuroinflammation.

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

Brian J Cummings, C. Cotman, C. Pike, 1995, Experimental Neurology.

Activation of Caspase-8 in the Alzheimer's Disease Brain

William H. Nesse, C. Cotman, E. Head, 2001, Neurobiology of Disease.

Neuronal Apoptosis Induced by β-Amyloid Is Mediated by Caspase-8

C. Cotman, T. Rohn, K. J. Ivins, 1999, Neurobiology of Disease.

DNA Damage and Activated Caspase-3 Expression in Neurons and Astrocytes: Evidence for Apoptosis in Frontotemporal Dementia

C. Cotman, K. Tomaselli, Joseph H. Su, 2000, Experimental Neurology.

Caspase-3 activation as a bifurcation point between plasticity and cell death

C. Cotman, Erica D. Smith, G. A. Prieto, 2012, Neuroscience Bulletin.

Neuronotrophic activity for ciliary ganglion neurons. Induction following injury to the brain of neonatal, adult, and aged rats.

C. Cotman, M. Nieto‐Sampedro, C W Cotman, 1985, Brain research.

Neuritic Involvement within bFGf Immunopositive Plaques of Alzheimer's Disease

Brian J Cummings, C. Cotman, Joseph H. Su, 1993, Experimental Neurology.

Melatonin treatment in old mice enables a more youthful response to LPS in the brain

C. Cotman, V. Perreau, S. Bondy, 2007, Journal of Neuroimmunology.

C. Cotman, N. Berchtold, K. Green, 2014, Neurobiology of Aging.

Interleukin-1β interferes with signal transduction induced by neurotrophin-3 in cortical neurons

R. Balázs, C. Cotman, W. Thangnipon, 2008, Brain Research.

Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord

C. Cotman, C. Engesser-Cesar, A. Anderson, 2007, Neuroscience.

Differential regulation of inhibitors of apoptosis proteins in Alzheimer’s disease brains

C. Cotman, M. Dick, Jun Zhou, 2007, Neurobiology of Disease.

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro(*)

Carl W. Cotman, C. Cotman, C. Pike, 1995, The Journal of Biological Chemistry.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

C. Cotman, C. Glabe, D. Cribbs, 2008, Journal of Neuroinflammation.

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

M. J. Fresnadillo Martínez, H. Hakonarson, G. Schellenberg, 2010, Nature Genetics.

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology

Carl W. Cotman, Ming Zhao, C. Cotman, 2001, Brain Research.

β-Amyloid converts an acute phase injury response to chronic injury responses

Brian J Cummings, C. Cotman, A. Tenner, 1996, Neurobiology of Aging.

A microperfusion chamber for brain slice pharmacology

C. Cotman, J. F. Koerner, 1983, Journal of Neuroscience Methods.

Response of Schaffer collateral-CA1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids

C. Cotman, J. F. Koerner, 1982, Brain Research.

Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men.

C. Cotman, J. Cummings, P. Lu, 2006, Archives of neurology.

β-Amyloid neurotoxicity: A discussion of in vitro findings

C. Cotman, C. Pike, A. Copani, 1992, Neurobiology of Aging.

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

C. Cotman, D. Araujo, 1992, Brain Research.

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

C. Cotman, J. Koh, Linda L Yang, 1990, Brain Research.

An ultrastructural and chemical analysis of the effect of triton X-100 on synaptic plasma membranes.

W. Levy, C. Cotman, G. Banker, 1971, Biochimica et biophysica acta.

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

C. Cotman, K. Nichol, A. Parachikova, 2008, Neurobiology of Disease.

Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease

C. Cotman, A. Parachikova, Carl W. Cotman, 2007, Neurobiology of Disease.

Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation.

C. Cotman, J. Koh, A. Copani, 1991, Neuroreport.

Inhibition of [3H]α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin β-N-oxaly-L-α,β-diaminopropionic acid

P. Nunn, C. Cotman, D. Monaghan, 1988 .

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

Carl W. Cotman, Victoria M. Perreau, C. Cotman, 2009, The Journal of Neuroscience.

Stimulus-secretion coupling processes in brain: Dependence upon extracellular calcium concentration

W. Levy, C. Cotman, J. Haycock, 1979, Neuroscience.

The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro

C. Cotman, J. Nadler, W. White, 1979, Brain Research.

Regulatory Mechanisms of Synaptic Transmission

C. Cotman, R. Tapia, 1981, Springer US.

A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat.

G. Lynch, C. Cotman, B. Crain, 1973, Brain research.

Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease

G. Lynch, C. Cotman, H. Chui, 1988, Neurobiology of Aging.

Locomotor activity rhythms in dogs vary with age and cognitive status.

C. Cotman, N. Milgram, E. Head, 2003, Behavioral neuroscience.

Subsynaptosomal distribution of enzymes involved in the metabolism of lipids.

C. Cotman, R. Mccaman, S. Dewhurst, 1971, Biochimica et biophysica acta.

The binding of diphenylhydantoin to brain and subcellular fractions.

C. Cotman, T. Nielsen, 1971, European journal of pharmacology.

Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies

C. Cotman, F. Gomez-Pinilla, E. A. V. D. Wal, 1993 .

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

C. Cotman, C. Glabe, A. Henschen, 1992, The Journal of biological chemistry.

Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus

R. Balázs, C. Cotman, L. Tong, 2001, Neuroscience.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Elizabeth Head, C. Cotman, L. Breydo, 2007, Molecular neurodegeneration.

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.

C. Cotman, M. Vitek, F. LaFerla, 2004, The Journal of clinical investigation.

Initiation and propagation stages of β-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles

C. Cotman, Julene K. Johnson, R. McCleary, 1998, Brain Research.

β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

R. Balázs, C. Cotman, P. Thornton, 2004, The Journal of Neuroscience.

Identification of Synapse Specific Components: Synaptic Glycoproteins, Proteins, and Transmitter Binding Sites

G. Fagg, C. Cotman, A. Foster, 1981, Journal of neurochemistry.

Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation

C. Cotman, W. Ellis, V. Vijayan, 1991, Experimental Neurology.

Increased Immunoreactivity for Jun- and Fos-Related Proteins in Alzheimer's Disease: Association with Pathology

Brian J Cummings, C. Cotman, A. Anderson, 1994, Experimental Neurology.

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

C. Cotman, M. Dick, E. Wolters, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

C. Cotman, N. Berchtold, J. Rogers, 2012, Journal of Neuroinflammation.

Musashi1 antigen expression in human fetal germinal matrix development

C. Cotman, H. Okano, C. Svendsen, 2006, Experimental Neurology.

Life-Long Dietary Restriction Attenuates Age-Related Increases in Hippocampal Glial Fibrillary Acidic Protein mRNA

C. Cotman, C. Finch, J. Kesslak, 1997, Neurobiology of Aging.

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise

C. Cotman, V. Perreau, P. Adlard, 2004, Neuroscience Letters.

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.

C. Cotman, L. Packer, Zhongbo Liu, 2008, Free radical biology & medicine.

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease.

C. Cotman, B. Bahr, A. Anderson, 2001, The American journal of pathology.

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders

C. DeCarli, G. Small, D. Bennett, 2019, Alzheimer disease and associated disorders.

GADD45Is Induced in Alzheimer's Disease, and Protects against Apoptosisin Vitro

C. Cotman, Joseph H. Su, Gangmin Deng, 1998, Neurobiology of Disease.

miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

C. Cotman, F. LaFerla, M. Kitazawa, 2020, Aging cell.

Emerging roles of oxidative stress in brain aging and Alzheimer's disease

C. Cotman, Andra Ionescu-Tucker, 2021, Neurobiology of Aging.

The Role of Neurotrophins in Brain Aging: A Perspective in Honor of Regino Perez-Polo

C. Cotman, 2005, Neurochemical Research.

IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking

C. Cotman, G. A. Prieto, A. Carlos, 2017, Journal of Neuroinflammation.

The Induction of the TNFα Death Domain Signaling Pathway in Alzheimer's Disease Brain

Brian J Cummings, C. Cotman, A. Anderson, 2003, Neurochemical Research.

Bcl-2 Facilitates Recovery from DNA Damage after Oxidative Stress

C. Cotman, B. V. Houten, Joseph H. Su, 1999, Experimental Neurology.

The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

Elizabeth Head, C. Cotman, E. Head, 2008, Journal of Alzheimer's disease : JAD.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

C. Cotman, H. Paulson, V. Uversky, 2013, The Journal of clinical investigation.

Original Contribution Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction

C. Cotman, L. Packer, Zhongbo Liu, 2008 .

Oxidative damage increases with age in a canine model of human brain aging

B. Ames, C. Cotman, N. Milgram, 2002, Journal of neurochemistry.

Exercise Enhances and Protects Brain Function

Carl W. Cotman, Christie Engesser-Cesar, C. Cotman, 2002, Exercise and sport sciences reviews.

Inflammatory changes parallel the early stages of Alzheimer disease

C. Cotman, J. Rogers, V. Perreau, 2007, Neurobiology of Aging.

H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus

L. Overman, C. Cotman, G. A. Prieto, 2016, The Journal of Neuroscience.

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

C. Cotman, N. Berchtold, H. Northoff, 2016, Journal of Neuroinflammation.

Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration

C. Cotman, M. Sheetz, K. Pfister, 1998, Progress in Neurobiology.

Neurobiology of exercise

Barry E. Levin, V. Edgerton, S. Gandevia, 2006, Obesity.

Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia.

C. Cotman, E. R. Whittemore, A. Korotzer, 1995, European journal of pharmacology.

Carbachol increases intracellular free calcium in cultured rat microglia

C. Cotman, E. R. Whittemore, A. Etebari, 1993, Brain Research.

Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis

C. Cotman, C. Pike, A. Anderson, 1995 .

Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia

Melina R. Uncapher, C. Cotman, R. Haier, 2003, Neurology.

Parallel Compensatory and Pathological Events Associated with Tau Pathology in Middle Aged Individuals with Down Syndrome

C. Cotman, P. Hof, C. Bouras, 2003, Journal of neuropathology and experimental neurology.

Complement Association with Neurons and β-Amyloid Deposition in the Brains of Aged Individuals with Down Syndrome

C. Cotman, E. Head, D. Cribbs, 2001, Neurobiology of Disease.

Neurobiological Models of Aging in the Dog and Other Vertebrate Species

C. Cotman, N. Milgram, E. Head, 2001 .

Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?

C. Cotman, J. Geddes, J. Kahle, 1990, Progress in brain research.

Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion

C. Cotman, R. Kim, Joseph H. Su, 2001, Neurobiology of Aging.

Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes.

C. Cotman, R. Bridges, A. Chamberlin, 1994, European journal of pharmacology.

Stimulation of phosphoinositide hydrolysis by trans-(±)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium

C. Cotman, R. Bridges, Stephan S. Miller, 1993, Brain Research.

Carbohydrate composition of central nervous system synapses. Analysis of isolated synaptic junctional complexes and postsynaptic densities.

P. Kelly, C. Cotman, G. Banker, 1976, Biochimica et biophysica acta.

Maintenance and Regulation in Brain of Neurotransmission, Trophic Factors, and Immune Responses

C. Cotman, A. Korotzer, J. Kahle, 2011 .

Chapter 21 - Trophic Factors and Cell Adhesion Molecules Can Drive Dysfunctional Plasticity and Senile Plaque Formation in Alzheimer's Disease through a Breakdown in Spatial and Temporal Regulation

Brian J Cummings, C. Cotman, 1999 .

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

C. Cotman, A. Anderson, D. Cribbs, 2003, Neurobiology of Disease.

Multiple Pathways of Apoptosis in PC12 Cells

C. Cotman, K. J. Ivins, J. Ivins, 1999, The Journal of Biological Chemistry.

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

Brian J Cummings, C. Cotman, J. Geddes, 1992, Neuroscience.

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

Brian J Cummings, C. Cotman, A. Anderson, 1994, Neuroreport.

Molecular Dating of Senile Plaques in the Brains of Individuals with Down Syndrome and in Aged Dogs

C. Cotman, E. Head, R. Kim, 2000, Experimental Neurology.

Isolation of a membrane fraction enriched in nerve-end membranes from rat brain by zonal cetrifugation.

C. Cotman, N. Anderson, H. Mahler, 1968, Biochimica et biophysica acta.

Electroshock Effects on Brain Protein Synthesis: Relation to Brain Seizures and Retrograde Amnesia

C. Cotman, S. Zornetzer, J. McGaugh, 1971, Science.

Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system

P. Kelly, C. Cotman, G. Nicolson, 1976, The Journal of cell biology.

Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.

C. Cotman, L. Thal, M. Sano, 2000, JAMA.

Autoradiographic characterization of putative excitatory amino acid transport sites

C. Cotman, D. Monaghan, R. Bridges, 1990, Neuroscience.

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

P. Baldi, C. Cotman, N. Berchtold, 2019, Neurobiology of Aging.

Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome

C. Cotman, Julene K. Johnson, C. Glabe, 2001, Neurobiology of Disease.

The distribution of septal projections to the hippocampus of the rat

G. Lynch, C. Cotman, S. Mosko, 1973, The Journal of comparative neurology.

Developmental changes in morphology and molecular composition of isolated synaptic junctional structures

P. Kelly, C. Cotman, 1981, Brain Research.

15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis.

C. Cotman, D. Cribbs, S. Wong, 2001, Neuroreport.

Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid

Carl W. Cotman, C. Cotman, J. Nadler, 1980, Brain Research.

Tracing the dentate gyrus mossy fiber system with horseradish peroxidase histochemistry.

G. Lynch, C. Cotman, R. Smith, 1973, Experimental neurology.

Excitatory amino acid receptors in schizophrenia.

C. Cotman, J. Ułas, Jolanta Utas, 1993, Schizophrenia bulletin.

Olfactory memory in unmedicated schizophrenics

S. Potkin, C. Cotman, M. Buchsbaum, 1993, Schizophrenia Research.

Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex.

C. Cotman, J. Ułas, L. Nguyen, 1993, Neuroreport.

Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.

Paul Greengard, Steven G Potkin, P. Greengard, 2002, Archives of general psychiatry.

Synaptic localization of kainic acid binding sites

C. Cotman, D. Monaghan, A. Foster, 1981, Nature.

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

C. Cotman, D. Monaghan, J. Watkins, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury

C. Cotman, F. Gomez-Pinilla, M. Nieto‐Sampedro, 1989, Experimental Neurology.

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function

C. Cotman, C. Siwak-Tapp, N. Milgram, 2007, Neurobiology of Learning and Memory.

An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease

C. Cotman, D. Piomelli, G. Astarita, 2012, Neurobiology of Aging.

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

C. Cotman, F. LaFerla, M. Kitazawa, 2018, Aging cell.

Survival at low and growth of hippocampal neurons in defined medium density : advantages of a sandwich culture technique or low oxygen

Gregory J. Brewer, Carl W. Cotman, C. Cotman, 2002 .

Chloride and calcium ions reveal a pharmacologically distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data

G. Fagg, C. Cotman, A. Foster, 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

C. Cotman, N. Berchtold, D. Mastroeni, 2016, Alzheimer's & Dementia.

Exercise enhances memory consolidation in the aging brain

C. Cotman, N. Milgram, S. Snigdha, 2014, Front. Aging Neurosci..

Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy.

Brian J Cummings, C. Cotman, N. Milgram, 1995, Progress in brain research.

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

C. Cotman, J. Koh, E. Palmer, 1991, Proceedings of the National Academy of Sciences of the United States of America.

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

Brian J Cummings, C. Cotman, R. Shankle, 1996, Neurobiology of Aging.

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

Brian J Cummings, C. Cotman, 1995, The Lancet.

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

C. Cotman, F. LaFerla, T. Golde, 2019, Scientific Reports.

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.

C. Cotman, P. S. St George-Hyslop, R. Palmour, 2013, The American journal of pathology.

Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia

C. Cotman, N. Milgram, E. Head, 2006, Neurobiology of Learning and Memory.

Nutritional Antioxidant Enrichment and Improved Cognitive Function in Canines

C. Cotman, E. Head, 2005 .

The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology

C. Cotman, R. Rissman, W. Poon, 2005, Journal of neuropathology and experimental neurology.

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

C. Cotman, C. Siwak-Tapp, N. Milgram, 2008, Neurobiology of Aging.

Diffuse plaques contain C-terminal Aβ 42 and not Aβ 40: Evidence from cats and dogs

Brian J Cummings, C. Cotman, D. Selkoe, 1996, Neurobiology of Aging.

Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.

Brian J Cummings, C. Cotman, D. Selkoe, 1996, Neurobiology of aging.

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1*

C. Cotman, N. Berchtold, W. Poon, 2013, The Journal of Biological Chemistry.

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

C. Cotman, N. Berchtold, M. Murphy, 2012, Neurobiology of Aging.

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

Carl W. Cotman, Bernadeta Michalski, Margaret Fahnestock, 2010, Neurobiology of Aging.

Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines

R. Saunders, C. Cotman, E. Head, 2008, The Journal of comparative neurology.

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

C. Cotman, N. Milgram, E. Head, 2005, AGE.

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

C. Cotman, N. Milgram, E. Head, 2002, Neurobiology of Aging.

Dietary enrichment counteracts age-associated cognitive dysfunction in canines

C. Cotman, N. Milgram, E. Head, 2002, Neurobiology of Aging.

Adrenergic Receptors in Alzheimer’s Disease Brain: Selective Increases in the Cerebella of Aggressive Patients

C. Cotman, A. Russo-Neustadt, 1997, The Journal of Neuroscience.

Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat

C. Cotman, J. Kesslak, S. Neeper, 1995, Neuroscience Letters.

Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro

C. Cotman, C. Pike, 1995, Brain Research.

Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

C. Cotman, C. Pike, J. Weiss, 1994 .

Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus

C. Cotman, F. LaFerla, M. Leissring, 1999, Journal of neurochemistry.

A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog

C. Cotman, N. Milgram, E. Head, 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging.

Min-Ying Su, Sandra E Black, Elizabeth Head, 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging.

C. Cotman, N. Milgram, E. Head, 2003, Learning & memory.

Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility.

C. Cotman, N. Milgram, E. Head, 2002, Behavioral neuroscience.

β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine

Brian J Cummings, C. Cotman, N. Milgram, 1996, Neurobiology of Learning and Memory.

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

C. Cotman, N. Milgram, E. Head, 2004, Neurobiology of Aging.

Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy

Norton W. Milgram, C. Cotman, N. Milgram, 2002, Neuroscience & Biobehavioral Reviews.

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease

C. Cotman, E. Head, Joseph H. Su, 2003, Neurobiology of Disease.

Initiation and propagation of molecular cascades in human brain aging: Insight from the canine model to promote successful aging

C. Cotman, E. Head, P. Thornton, 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

C. Cotman, Erica D. Smith, G. A. Prieto, 2018, Neurochemical Research.

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models

C. Cotman, F. LaFerla, S. Forner, 2019, Aging cell.

Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease

C. Cotman, J. Geddes, 1986, Neuroscience Research.

Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice

C. Cotman, H. Vinters, J. LaManna, 2002, Annals of the New York Academy of Sciences.

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease

Carl W. Cotman, Brian J Cummings, Brian J. Cummings, 1993, Brain Research.

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

C. Cotman, C. Glabe, Haixiang Jiang, 1994, Journal of immunology.

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.

C. Cotman, D. Gurwitz, J. Geddes, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Plasticity in Alzheimer's disease: Too much or not enough?

C. Cotman, J. Geddes, 1991, Neurobiology of Aging.

Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro.

C. Cotman, C. Pike, M. Overman, 1995, The Journal of biological chemistry.

Isolated Executive Impairment and Associated Frontal Neuropathology

Brent A. Vogt, Carl W. Cotman, Elizabeth Head, 2004, Dementia and Geriatric Cognitive Disorders.

Clinical and pathological evidence for a frontal variant of Alzheimer disease.

C. Cotman, A. Starr, E. Head, 1999, Archives of neurology.

Reactive Synaptogenesis in the Adult Nervous System

G. Lynch, C. Cotman, 1976 .

Basic Fibroblast Growth Factor in the Mature Brain and Its Possible Role in Alzheimer's Disease

C. Cotman, F. Gomez-Pinilla, 1991, Annals of the New York Academy of Sciences.

Complex Learning and Memory

C. Cotman, J. McGaugh, 1980 .

Do neurotrophic interactions control synapse formation in the adult rat brain?

C. Cotman, D. Goldowitz, 1980, Brain Research.

Intracellular responses from granule cell layer in slices of rat hippocampus: perforant path synapse.

G. Lynch, S. Deadwyler, C. Cotman, 1976, Journal of neurophysiology.

Intracellular responses of rat dentate granule cellsin vitro: posttetanic potentiation to perforant path stimulation

G. Lynch, S. Deadwyler, C. Cotman, 1975, Brain Research.

C. Cotman, K. Magnusson, 1993, Neurobiology of Aging.

Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting.

C. Cotman, S. Scheff, 1977, Behavioral biology.

Effects of Exercise on Gene-Expression Profile in the Rat Hippocampus

R. Balázs, C. Cotman, V. Perreau, 2001, Neurobiology of Disease.

Axonal transport and axon sprouting in the adult rat dentate gyrus: An autoradiographic study

C. Cotman, D. Goldowitz, 1980, Neuroscience.

Clinical trials: new opportunities.

M. Gallagher, C. Cotman, S. Chapman, 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by l-2-amino-4-phosphonobutanoic acid (l-AP4)

C. Cotman, E. R. Whittemore, 1991, Brain Research.

Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site

C. Cotman, E. Harris, D. Stevens, 1987, Brain Research.

Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea‐pig hippocampus.

A. Ganong, C. Cotman, J. A. Flatman, 1986, The Journal of physiology.

Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices

A. Ganong, C. Cotman, Timothy J. Hearn, 1986, Brain Research.

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

Carl W. Cotman, C. Cotman, James F. Koerner, 1981, Brain Research.

Exposure of Astrocytes to Thrombin Reduces Levels of the Metabotropic Glutamate Receptor mGluR5

C. Cotman, C. Romano, N. Sehati, 1996, Journal of neurochemistry.

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.

C. Cotman, D. Monaghan, E. Palmer, 1988, Brain research.

Alterations in [3H]kainate and N-methyl-d-aspartate-sensitive l-[3H]-glutamate binding in the rat hippocampal formation following fimbria-fornix lesions

G. Buzsáki, C. Cotman, J. Geddes, 1992, Experimental Neurology.

Protein and glycoprotein composition of synaptic junctions prepared from discrete synaptic regions and different species

P. Kelly, C. Cotman, J. Rostas, 1979, Brain Research.

Exercise and Sodium Butyrate Transform a Subthreshold Learning Event into Long-Term Memory via a Brain-Derived Neurotrophic factor-Dependent Mechanism

C. Cotman, N. Berchtold, M. Wood, 2013, Neuropsychopharmacology.

Regeneration of rat hippocampal fimbria fibers after fimbria transection and peripheral nerve or fetal hippocampal implantation

G. Fagg, C. Cotman, J. S. Wendt, 1983, Experimental Neurology.

Elementary Learning and Behavioral Plasticity

C. Cotman, J. McGaugh, 1980 .

Anatomical organization of excitatory amino acid receptors and their properties.

C. Cotman, D. Monaghan, 1986, Advances in experimental medicine and biology.

Histochemical detection of orthograde degeneration in the central nervous system of the rat.

G. Lynch, O. Steward, C. Cotman, 1973, Brain research.

Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion

C. Cotman, N. Berchtold, J. Kesslak, 2003, Brain Research.

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse

C. Cotman, K. Nichol, A. Parachikova, 2007, Behavioural Brain Research.

Anatomical evidence for a projection from the entorhinal cortex to the contralateral dentate gyrus of the rat

G. Lynch, O. Steward, C. Cotman, 1975, Experimental Neurology.

Induction of basic fibroblast growth factor in Alzheimer's disease pathology.

Brian J Cummings, C. Cotman, F. Gomez-Pinilla, 1990, Neuroreport.

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

C. Cotman, J. Geddes, F. Miller, 1990, Neuroscience Letters.

Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices.

C. Cotman, N. Jeon, D. Cribbs, 2007, Journal of Visualized Experiments.

Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript.

C. Cotman, N. Berchtold, P. Isackson, 1999, Brain research. Molecular brain research.

Distribution of basic fibroblast growth factor in the developing rat brain

C. Cotman, F. Gomez-Pinilla, J.W.-K. Lee, 1994, Neuroscience.

Subpopulations of dystrophic neuritis in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics

Brian J Cummings, C. Cotman, Joseph H. Su, 1994, Brain Research.

β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

Brian J Cummings, C. Cotman, Joseph H. Su, 1993, Neurobiology of Aging.

Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study

C. Cotman, Fernando Go´mez-Pinilla, 1993, Brain Research.

bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy

Brian J Cummings, C. Cotman, G. J. Yee, 1992, Brain Research.

Physical activity and the maintenance of cognition: Learning from animal models

Carl W. Cotman, C. Cotman, N. Berchtold, 2007, Alzheimer's & Dementia.

Localization and Cell Association of C1q in Alzheimer's Disease Brain

Brian J Cummings, C. Cotman, D. Cribbs, 1996, Experimental Neurology.

Title BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p 38 MAPK Permalink

C. Cotman, D. Cribbs, E. Kramár, 2013 .

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells

C. Cotman, J. Fike, C. Limoli, 2009, Proceedings of the National Academy of Sciences.

Synapses and Epigenetics in the Alzheimer ’ s Brain

C. Cotman, N. Berchtold, D. Mastroeni, 2013 .

An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts

Gary Lynch, Carl Cotman, G. Lynch, 1976, Brain Research.

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap

C. Cotman, S. Weintraub, N. Fortin, 2013, Neurobiology of Aging.

The coulometric titration of weak acids in non-aqueous media

C. Cotman, J. Hickey, T. Williams, 1965 .

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus.

C. Cotman, N. Berchtold, P. Isackson, 1998, Brain research. Molecular brain research.

Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities.

G. Lynch, C. Cotman, D. A. Matthews, 1974, Developmental biology.

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

C. Cotman, N. Berchtold, J. Kesslak, 2005, Neuroscience.

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis

C. Cotman, V. Perreau, D. Lahiri, 2007, Neurochemistry International.

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase

G. Lynch, C. Cotman, D. Cribbs, 2012, The Journal of Neuroscience.

Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity

C. Cotman, J. Nadler, 1978, Brain Research.

β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants

C. Cotman, C. Pike, Nima Ramezan-Arab, 1997, Journal of neurochemistry.

Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.

C. Cotman, C. Pike, J. Weiss, 1994, Journal of neurochemistry.

BioVision: An application for the automated image analysis of histological sections

Yoshiyuki Inagaki, Charles Chubb, Phillip Sheu, 2006, Neurobiology of Aging.

Apolipoprotein E and Alzheimer’s Disease

Brian, Stanley, Anderton, 1996, Research and Perspectives in Alzheimer’s Disease.

Enhancement of spatial-temporal reasoning after a Mozart listening condition in Alzheimer's disease: a case study.

G L Shaw, C. Cotman, G. Shaw, 1998, Neurological research.

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

D. Geschwind, C. DeCarli, C. Cotman, 2015, JAMA neurology.

N-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis andPapio papio)

C. Cotman, B. Meldrum, S. Patel, 1989, Neuroscience.

C. Cotman, C. Pike, C. Glabe, 1991, European journal of pharmacology.

Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state

C. Cotman, M. Smyth, J. Kesslak, 1994, Neurobiology of Aging.

Effects of polyvalent cations on stimulus-coupled secretion of (14C)-gamma-aminobutyric acid from isolated brain synaptosomes.

W. Levy, C. Cotman, J. Haycock, 1974, Molecular pharmacology.

Horseradish peroxidase histochemistry: a new method for tracing efferent projections in the central nervous system.

G. Lynch, C. Cotman, C. Gall, 1974, Brain research.

Plaque biogenesis in brain aging and Alzheimer’s disease. II. Progressive transformation and developmental sequence of dystrophic neurites

Brian J Cummings, C. Cotman, J. Su, 1998, Acta Neuropathologica.

Transneuronal Degeneration in the Spread of Alzheimer's Disease Pathology: Immunohistochemical Evidence for the Transmission of Tau Hyperphosphorylation

C. Cotman, Joseph H. Su, Gangmin Deng, 1997, Neurobiology of Disease.

Plaque biogenesis in brain aging and Alzheimer's disease I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments

Brian J Cummings, C. Cotman, Joseph H. Su, 1996, Brain Research.

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and α-synuclein pathology

D. Bennett, C. Cotman, R. Rissman, 2005, Acta Neuropathologica.

Senile plaques as aberrant sprout-stimulating structures

C. Cotman, J. Geddes, K. Anderson, 1986, Experimental Neurology.

A new type of lesion-induced synaptogenesis: I. Synaptic turnover in non-denervated zones of the dentate gyrus in young adult rats

C. Cotman, S. Scheff, S. Hoff, 1981, Brain Research.

Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in alzheimer hippocampus: A quantitative autoradiographic study

C. Cotman, C. W. Cotman, J. Ułas, 1993, Neuroscience.

IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking

C. Cotman, G. A. Prieto, A. Carlos, 2017, Journal of Neuroinflammation.

The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain

G. Lynch, C. Cotman, 1975 .

Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.

C. Cotman, F. Gomez-Pinilla, E. A. van der Wal, 1993, Neuroreport.

Mild stress facilitates learning and exercise improves retention in aged mice

Carl W. Cotman, Paul A. Adlard, Christie Engesser-Cesar, 2011, Experimental Gerontology.

Pattern separation and goal-directed behavior in the aged canine

Shikha Snigdha, Michael A. Yassa, Christina deRivera, 2017, Learning & memory.

The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity

C. Cotman, M. Chen, A. Russo-Neustadt, 2003, Neuroscience.

Isolation and characterization of insoluble proteins of the synaptic plasma membrane.

C. Cotman, T. Hugli, H. Mahler, 1968, Archives of biochemistry and biophysics.

Ultrastructural analyses of β-amyloid in the aged dog brain: Neuronal β-amyloid is localized to the plasma membrane

C. Cotman, E. Head, R. Torp, 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane.

C. Cotman, E. Head, R. Torp, 2000, Progress in neuro-psychopharmacology & biological psychiatry.

Visual-discrimination learning ability and β-amyloid accumulation in the dog

C. Cotman, N. Milgram, E. Head, 1998, Neurobiology of Aging.

The progression of beta-amyloid deposition in the frontal cortex of the aged canine.

Brian J Cummings, C. Cotman, K. Nielson, 1997, Brain research.

Spatial learning and memory as a function of age in the dog.

Brian J Cummings, C. Cotman, N. Milgram, 1995, Behavioral neuroscience.

Induction of a neurite-promoting factor in rat brain following injury or deafferentation

C. Cotman, M. Nieto‐Sampedro, C. W. Cotman, 1986, Neuroscience.

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

C. Cotman, L. Thal, M. Sano, 2013 .

Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats.

G. Lynch, C. Cotman, D. A. Matthews, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance?

C. Cotman, J. Kesslak, F. Gomez-Pinilla, 1998, Behavioral neuroscience.

Multiple Excitatory Amino Acid Receptor Regulation of Intracellular Ca2+ Implications for Aging and Alzheimer's Disease

C. Cotman, D. Monaghan, 1989, Annals of the New York Academy of Sciences.

AMultiancestral Genome-Wide Exome Array Study of Alzheimer Disease , Frontotemporal Dementia , and Progressive Supranuclear Palsy

D. Geschwind, C. Cotman, A. Levey, 2015 .

Long-term survival of neural transplants to senescence in rats

C. Cotman, J. Geddes, R. Gibbs, 1990, Experimental Neurology.

Synaptic Plasticity and Aging

C. Cotman, C. Peterson, 1990 .

Twelve – Synaptic Plasticity, Neurotrophic Factors, and Transplantation in the Aged Brain

C. Cotman, 1990 .

Factors affecting survival and outgrowth from transplants of entorhinal cortex

C. Cotman, R. Gibbs, Carl W. Cotman, 1987, Neuroscience.

Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation

C. Cotman, J. Kesslak, M. Nieto‐Sampedro, 1986, Experimental Neurology.

The control of glial populations in brain: Changes in astrocyte mitogenic and morphogenic factors in response to injury

C. Cotman, M. Nieto‐Sampedro, J. Vellis, 1985, Brain Research.

Replacement of damaged cortical projections by homotypic transplants of entorhinal cortex

C. Cotman, E. Harris, R. Gibbs, 1985, The Journal of comparative neurology.

Turnover of brain postsynaptic densities after selective deafferentation: detection by means of an antibody to antigen PSD-95

C. Cotman, C. Bussineau, M. Sampedro, 1982, Brain Research.

Mechanisms of septal lamination in the developing hippocampus analyzed by outgrowth of fibers from septal implants. II. Absence of guidance by degenerative debris

C. Cotman, E. R. Lewis, 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors

C. Cotman, E. R. Lewis, 1980, Brain Research.

Stimulus-Coupled Secretion of γ-Aminobutyric Acid from Rat Brain Synaptosomes

W. Levy, C. Cotman, D. Redburn, 1973, Science.

Identification of cell types in rat hippocampal slices maintained in organotypic cultures.

C. Cotman, R. Beach, S. Bathgate, 1982, Brain research.

Isolation, morphology, and protein and glycoprotein composition of synaptic junctional fractions from the brain of lower vertebrates: antigen PSD-95 as a junctional marker

C. Cotman, M. Nieto‐Sampedro, C. Bussineau, 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Synaptic cleft glycoproteins contain homologous amino acid sequences.

C. Cotman, E. Mena, 1982, Science.

Molecular Composition of Synaptic Junctions and Post-Synaptic Densities: A Functional Perspective

C. Cotman, E. Mena, M. Sampedro, 1982 .

Intermolecular disulfide bonds at central nervous system synaptic junctions.

P. Kelly, C. Cotman, 1976, Biochemical and biophysical research communications.

Ionic regulation of glutamate binding sites.

C. Cotman, D. Monaghan, S. Whittemore, 1984, Life sciences.

Regional distribution and ionic requirement of Cl−/Ca2+-activated and Cl−/Ca2+-independent glutamate receptors in rat brain

C. Cotman, D. Monaghan, S. Whittemore, 1983, Brain Research.

N-Acetylaspartylglutamate identified in the rat retinal ganglion cells and their projections in the brain

C. Cotman, J. Neale, J. Moffett, 1987, Brain Research.

Microsoft Word-EDSmith_mTOR_neurons3.docx

O. Steward, C. Cotman, Erica D. Smith, 2014 .

Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous.

C. Cotman, R. Rissman, E. Head, 2002, Drug news & perspectives.

The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer's Disease Pathology

Carl W. Cotman, Brian J Cummings, C. Cotman, 1991 .

Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression

C. Cotman, P. Adlard, 2004, Neuroscience.

Stimulation-dependent depression of neurotransmitter release in brain: [Ca2+]0 dependence

William B. Levy, Carl W. Cotman, John W. Haycock, 1978, Brain Research.

A perfusion chamber for the study of CNS physiology and pharmacology in vitro

C. Cotman, J. Nadler, W. White, 1978, Brain Research.

Selective Loss of N‐Methyl‐d‐Aspartate‐Sensitive l‐[3H]Glutamate Binding Sites in Rat Brain Following Portacaval Anastomosis

C. Cotman, R. Butterworth, J. Giguère, 1990, Journal of neurochemistry.

Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid

C. Cotman, C. Pike, Christian J. Pike, 1993, Neuroscience.

Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain

Wanlin Zhu, Carl Cotman, Michael J. Valenzuela, 2013, Biological Psychiatry.

Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus.

G. Lynch, C. Cotman, J. Nadler, 1974, Brain research.

Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner

C. Cotman, N. Berchtold, D. Matheos, 2021, Frontiers in Aging Neuroscience.

Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression

C. Cotman, A. Russo-Neustadt, R. Beard, 1999, Neuropsychopharmacology.

Plasticity and growth factors in injury response

C. Cotman, N. Berchtold, 1998 .

Exercise improves cognition and hippocampal plasticity in APOE ε4 mice

Carl W. Cotman, C. Cotman, Sean P. Deeny, 2009, Alzheimer's & Dementia.

Voluntary running attenuates age-related deficits following SCI

Carl W. Cotman, C. Cotman, N. Berchtold, 2008, Experimental Neurology.

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.

C. Cotman, J. Geddes, S. Wagner, 1989, Nature.

Signaling Mechanisms that Mediate Aβ Induced Neuronal Dysfunction

C. Cotman, J. Busciglio, 2007 .

Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker

C. Cotman, J. Geddes, J. Kesslak, 1990, Neuroscience.

Immunocytochemical localization of serotonin in the rat dentate gyrus following raphe transplants

C. Cotman, R. Lasher, V. Holets, 1986, Brain Research.

Plastic response of hippocampal excitatory amino acid receptors to deafferentation and reinnervation

C. Cotman, D. Monaghan, J. Ułas, 1990, Neuroscience.

Role of Excitatory Amino Acids in the Development of Cerebellar Granule Neurones

R. Balázs, C. Cotman, V. Gallo, 1988 .

l-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis

C. Cotman, D. Monaghan, D. Yao, 1985, Brain Research.

Acidic amino acid antagonists of lateral perforant path synaptic transmission: agonist—antagonist interactions in the dentate gyrus

A. Ganong, C. Cotman, 1982, Neuroscience Letters.

Structure-activity relationships of l-glutamate receptor ligands: Role of the ω-acidic terminal

G. Fagg, C. Cotman, E. Harris, 1982, Neuroscience Letters.

Metabotropic glutamate receptors in cerebral cortical astrocytes: pharmacological properties of mGluR5 and interaction between PLC-and adenylate cyclase (AC)-coupled transduction systems

R. Balázs, C. Cotman, C. Romano, 1996, Neuropharmacology.

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity.

C. Cotman, C. Pike, C. Glabe, 1991, Brain research.

The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

C. Cotman, E. Head, M. Fonseca, 1999, Experimental neurology.

Relative potency of analogues of excitatory amino acids on hippocampal CA1 neurons

C. Cotman, T. Lanthorn, 1983, Neuropharmacology.

REACTIVE SYNAPTOGENESIS IN THE ADULT CNS

C. Cotman, 1983 .

DENSITIES: A FUNCTIONAL PERSPECTIVE

C. Cotman, E. Mena, M. Sampedro, 1982 .

Active rule processing in the BioCompose database

Taehyung Wang, Phillip C.-Y. Sheu, Carl Cotman, 1998, Proceedings First International Symposium on Object-Oriented Real-Time Distributed Computing (ISORC '98).

Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers

C. Cotman, Joseph C. Wu, Sean P. Deeny, 2012, Alzheimer's & Dementia.

Dietary and Behavioral Interventions Protect against Age Related Activation of Caspase Cascades in the Canine Brain

C. Cotman, N. Berchtold, D. Piomelli, 2011, PloS one.

Healthy brain aging: A meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging

John Q. Trojanowski, Carl Cotman, Marilyn Albert, 2008, Alzheimer's & Dementia.

Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions: I. Time course after complete unilateral entorhinal lesion at various ages

G. Lynch, C. Cotman, J. Nadler, 1977, The Journal of comparative neurology.

Oligodendrocyte degeneration in AD

C. Cotman, G. T. Whitman, 2004, Neurobiology of Aging.

Changes in the distribution of the dentate gyrus associational system following unilateral or bilateral entorhinal lesions in the adult rat

G. Lynch, G. Rose, C. Cotman, 1976, Brain Research.

Spine Loss and Regrowth in Hippocampus following Deafferentation

G. Lynch, C. Cotman, A. Globus, 1974, Nature.

Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells.

C. Cotman, W. V. Van Nostrand, J. Davis-Salinas, 1995, Journal of neurochemistry.

Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy

C. Cotman, J. Geddes, R. Kim, 1990, Experimental Neurology.

Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia

C. Cotman, D. Cribbs, A. Tenner, 1995, Experimental Neurology.

The Variability of Practice Hypothesis in Motor Learning: Does It Apply to Alzheimer's Disease?

D. S. Davis, C. Cotman, M. Dick, 2000, Brain and Cognition.

Acquisition and long-term retention of a gross motor skill in Alzheimer's disease patients under constant and varied practice conditions.

C. Cotman, M. Dick, R. Shankle, 1996, The journals of gerontology. Series B, Psychological sciences and social sciences.

Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity

C. Cotman, N. Berchtold, M. Wood, 2019, Learning & memory.

Exercise in Neurodegenerative Disease and Stroke

C. Cotman, M. Zigmond, T. Schallert, 2009 .

Alzheimer research forum live discussion: Brain derived neurotrophic factor and Alzheimer's disease - What is the connection?

C. Cotman, N. Berchtold, G. Strobel, 2005 .

Hearing, Tasting and Smelling, and Feeling

C. Cotman, J. McGaugh, 1980 .

Regulation of glutamate receptors: possible role of phosphatidylserine

G. Fagg, C. Cotman, E. Harris, 1982, Brain Research.

Acquisition and Long-Term Retention of a Fine Motor Skill in Alzheimers-Disease

C. Cotman, K. Nielson, M. Dick, 1995, Brain and Cognition.

Plasticity, pathology, and Alzheimer's disease

C. Cotman, J. Geddes, 1989, Neurobiology of Aging.

Response latency in Canis familiaris: mental ability or mental strategy?

C. Cotman, N. Milgram, E. Head, 2003, Behavioral neuroscience.

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

C. Cotman, E. Head, V. Vasilevko, 2010, Neurobiology of Disease.

Impairment of Neurotrophin-3-Induced Phosphorylation of cAMP Response Element-Binding Protein Caused by Interleukin-1β in Cultured Cortical Neurons

C. Cotman, W. Thangnipon, R. Soi-ampornkul, 2006 .

Immunization with fibrillar Aβ1–42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ

C. Cotman, M. Murphy, N. Milgram, 2006 .

Molecular markers of reactive plasticity.

C. Cotman, J. Geddes, F. Miller, 1990, Advances in experimental medicine and biology.

Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal

C. Cotman, S. Scheff, L. Benardo, 1980, Brain Research.

Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease.

C. Cotman, C W Cotman, K J Anderson, 1988, Advances in neurology.

Why Am I What I Am

C. Cotman, J. McGaugh, 1980 .

Synaptic Plasticity vs Pathology in Alzheimer’s Disease: Implications for Transplantation

C. Cotman, 1989 .

N‐methyl‐D‐aspartate receptors, synaptic plasticity, and Alzheimer's disease

C. Cotman, D. Monaghan, J. Geddes, 1989 .

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.

Brian J Cummings, C. Cotman, A. Anderson, 2003, Neurochemical research.

Relocation and hyperdevelopment of the dentate gyrus commissural system after entorhinal lesions in immature rats.

G. Lynch, C. Cotman, S. Mosko, 1973, Brain research.

Surface determinants of neuronal survival and growth on self-assembled monolayers in culture

C. J. Pike, C. Cotman, D. Stenger, 1993, Brain Research.

Spatial patterns of mammalian brain aging: Distribution of cathepsin D–immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease

G. Lynch, C. Cotman, X. Bi, 2003, The Journal of comparative neurology.

Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons.

C. Cotman, N. Jeon, D. Cribbs, 2007, Journal of visualized experiments : JoVE.

Human brain tumor cyst fluid is mitogenic for primary astrocytes in culture.

C. Cotman, J. H. Neal, 1993, Neurosurgery.

A l-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes

C. Cotman, J. Kesslak, M. Nieto‐Sampedro, 1987, Brain Research.

Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography

C. Cotman, D. Monaghan, D. Yao, 1984, Brain Research.

On the road towards the global analysis of human synapses

C. Cotman, G. A. Prieto, 2017, Neural regeneration research.

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

C. Cotman, G. A. Prieto, L. Tong, 2018, Journal of Neuroinflammation.

Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Preliminary studies.

M S Buchsbaum, G Lynch, N Sicotte, 1991, Archives of general psychiatry.

Synergistic Effects of Long-Term Antioxidant Diet and Behavioral Enrichment on β-Amyloid Load and Non-Amyloidogenic Processing in Aged Canines

C. Cotman, N. Berchtold, M. Murphy, 2010, The Journal of Neuroscience.

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

C. Cotman, N. Berchtold, F. LaFerla, 2015, Proceedings of the National Academy of Sciences.

Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites.

C. Cotman, Erica D. Smith, G. A. Prieto, 2019, ACS chemical neuroscience.

Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog

C. Cotman, N. Milgram, E. Head, 2000, Behavioural Brain Research.

Perineuronal satellitosis in the human hippocampal formation

C. Cotman, W. Ellis, M. Russell, 1993, Hippocampus.

Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks

C. Cotman, N. Milgram, E. Head, 2004, Behavioural Brain Research.

Entorhinal transplants and spatial memory abilities in rats

C. Cotman, R. Gibbs, Jen Yu, 1987, Behavioural Brain Research.

Calcium-dependent release of (14C)GABA from vinblastine and colchicine treated synaptosomes.

C. Cotman, D. Redburn, 1974, Brain research.

Development of a protocol for studying object recognition memory in the dog

Norton W. Milgram, Carl W. Cotman, Elizabeth Head, 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Receptor‐coupled phospholipase C and adenylyl cyclase function with different calcium pools in astrocytes

R. Balázs, C. Cotman, Stephan S. Miller, 1998, Neuroreport.

Axon Sprouting and Regeneration

C. Cotman, 1999 .

Decreases in protease nexins in Alzheimer's disease brain

C. Cotman, R. Kim, P. Vaughan, 1995, Neurobiology of Aging.

The Critical Afferent Theory: A Mechanism to Account for Septohippocampal Development and Plasticity

C. Cotman, E. R. Lewis, D. Hand, 1981 .

Estrogen regulates bcl-x expression in rat hippocampus

C. Cotman, N. Berchtold, C. Pike, 2001, Neuroreport.

Integration: Putting It All Together

C. Cotman, J. McGaugh, 1980 .

β-Amyloid peptides induce degeneration of cultured rat microglia

C. Cotman, C. Pike, A. Korotzer, 1993, Brain Research.

Growth of a new fiber projection in the brain of adult rats: Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions

G. Lynch, O. Steward, C. Cotman, 1974, Experimental Brain Research.

Development of afferent lamination in the fascia dentata of the rat

G. Lynch, C. Cotman, R. Loy, 1977, Brain Research.

Developmental differences in post-lesion axonal growth in the hippocampus.

G. Lynch, C. Cotman, B. Stanfield, 1973, Brain research.

N-methyl-d-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease

C. Cotman, J. Geddes, J. Ułas, 1992, Neuroscience.

The Neuro-Immune Endocrine Connection

Carl W. Cotman, C. Cotman, R. Brinton, 1987 .

Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: Non-N-methyl-d-aspartate receptors

C. Cotman, J. Geddes, J. Ułas, 1992, Neuroscience.

Recruitment of a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial

A. LaCroix, C. Cotman, H. Feldman, 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro.

C. Cotman, C. Pike, 1995, Brain Research.

Compensatory synapse growth in aged animals after neuronal death

C. Cotman, S. Scheff, 1979, Mechanisms of Ageing and Development.

Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex

C. Cotman, J. Kesslak, A. Song, 1991, Brain Research.

Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I

C. Cotman, J. Rowe, M. Nieto‐Sampedro, 1987, Brain Research.

Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease.

C. Cotman, J. Geddes, M. Klein, 1990, Progress in brain research.

Time-dependent changes in commissural field potentials in the dentate gyrus following lesions of the entorhinal cortex in adult rats

G. Lynch, S. Deadwyler, C. Cotman, 1975, Brain Research.

Evidence for selective post-lesion axonal growth in the dentate gyrus of the rat.

G. Lynch, C. Cotman, B. Stanfield, 1974, Brain research.

Postlesion Axonal Growth Produces Permanent Functional Connections

G. Lynch, S. Deadwyler, C. Cotman, 1973, Science.

The survival of brain transplants is enhanced by extracts from injured brain.

C. Cotman, M. Nieto‐Sampedro, S. Whittemore, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. III. Competitive interactions

C. Cotman, E. R. Lewis, 1982, Brain Research.

Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid

C. Cotman, J. Nadler, C. Gentry, 1981, The Journal of comparative neurology.

Regional distribution of [3H]kainic acid after intraventricular injection.

C. Cotman, J. Nadler, B. W. Perry, 1980, Life sciences.

Potentiation of excitatory synaptic transmission in the normal and in the reinnervated dentate gyrus of the rat

G. Lynch, O. Steward, C. Cotman, 1976, Experimental Brain Research.

Electrophysiological analysis of the projection from the contralateral entorhinal cortex to the dentate gyrus in normal rats

G. Lynch, C. Cotman, W. White, 1976, Brain Research.

A dual marking technique for microelectrode tracks and localization recording sites.

G. Lynch, S. Deadwyler, C. Cotman, 1975, Electroencephalography and clinical neurophysiology.

Re-establishment of electrophysiologically functional entorhinal cortical input to the dentate gyrus deafferented by ipsilateral entorhinal lesions: Innervation by the contralaeral entorhinal cortex

G. Lynch, O. Steward, C. Cotman, 1973, Experimental Brain Research.

Basic Principles of Neuronal Signaling

C. Cotman, J. McGaugh, 1980 .

Ultrastructural characterization of identified cholinergic neurons transplanted to the hippocampal formation of the rat

C. Cotman, P. Salvaterra, R. Gibbs, 1986, The Journal of comparative neurology.

A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture

C. Cotman, J. Koh, A. Lin, 1991, Brain Research.

Preserved cerebellar tyrosine hydroxylase-immunoreactive neuronal fibers in a behaviorally aggressive subgroup of Alzheimer's disease patients

C. Cotman, A. Russo-Neustadt, T. Zomorodian, 1998, Neuroscience.

Elevated NMDA receptors in parkinsonian striatum.

J. Marshall, C. Cotman, F. Weihmuller, 1992, Neuroreport.

Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat

G. Lynch, C. Cotman, K. Lee, 1977, Experimental Brain Research.

Rational pattern design for in vitro cellular networks using surface photochemistry

Carl W. Cotman, James J. Hickman, Judy N. Quong, 1994 .

Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion

C. Cotman, J. Nadler, B. W. Perry, 1980, Experimental Neurology.

Lesion-induced synaptogenesis in brain: a study of dynamic changes in neuronal membrane specializations.

C. Cotman, 1976, Journal of supramolecular structure.

Ultrastructural changes in synapses in the dentate gyrus of the rat during development

G. Lynch, C. Cotman, Dwan A. Taylor, 1973 .

Decreased expression of N-methyl-d-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain

C. Cotman, J. Ułas, 1997, Neuroscience.

Adrenal hormone effects on hippocampal excitatory amino acid binding

C. Cotman, A. S. Clark, 1992, Brain Research.

N-methyl-D-aspartate receptors and Alzheimer's disease

C. Cotman, D. Monaghan, J. Geddes, 1989, Neurobiology of Aging.

[3H]TCP binding sites in Alzheimer's disease

C. Cotman, D. Monaghan, J. Geddes, 1987, Neuroscience Letters.

Autoradiography of d-2-[3H]amino-5-phosphonopentanoate binding sites in rat brain

C. Cotman, D. Monaghan, J. Watkins, 1984, Neuroscience Letters.

Excitatory Amino Acid Synapses: Studies of Normal and Reorganized Pathways

C. Cotman, 1988 .

L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.

C. Cotman, J. Kahle, 1993, The Journal of pharmacology and experimental therapeutics.

Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path

C. Cotman, E. Harris, C. W. Cotman, 2004, Experimental Brain Research.

Freezing eliminates a specific population of l-glutamate receptors in synaptic membranes

G. Fagg, C. Cotman, D. Monaghan, 1983, Neuroscience Letters.

The specificity of reactive synaptogenesis: A comparative study in the adult rat hippocampal formation

C. Cotman, S. Scheff, D. Goldowitz, 1979, Brain Research.

Excitatory amino acid receptors and ischemic brain damage in the rat

C. Cotman, D. Monaghan, T. Wieloch, 1987, Neuroscience Letters.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

C. Cotman, C. Glabe, D. Cribbs, 2022 .

Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection

C. Cotman, F. Gomez-Pinilla, C. Cotman, 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

Margaret A. Pericak-Vance, John X. Morris, Jonathan L. Haines, 2012, Neurology.

Effect of serial lesions on sprouting in the dentate gyrus: Onset and decline of the catalytic effect

C. Cotman, S. Scheff, L. Benardo, 1978, Brain Research.

Specificity of synaptic growth in brain: remodeling induced by kainic acid lesions.

C. Cotman, C. W. Cotman, 1979, Progress in brain research.

Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons

Carl W. Cotman, James J. Hickman, Joseph J. Pancrazio, 1998, Journal of Neuroscience Methods.

Lesion-induced vascular changes in the dentate gyrus following removal of the entorhinal cortex in adult rats

C. Cotman, S. Scheff, L. Benardo, 1978, Experimental Neurology.

Progressive brain damage accelerates axon sprouting in the adult rat.

C. Cotman, S. Scheff, I. Benardo, 1977, Science.

The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain.

C. Cotman, C. Vaegter, K. Larsen, 2023, Aging cell.

Regulation of acetylcholine muscarinic receptors by embryonic septal grafts showing cholinergic innervation of host hippocampus.

J. Joyce, J. Marshall, C. Cotman, 1988, Progress in brain research.

Neonatal septal implants: Development of afferent lamination in the rat dentate gyrus

C. Cotman, E. R. Lewis, J. C. Mueller, 1980, Brain Research Bulletin.

A new type of lesion-induced synaptogenesis: II. The effect of aging on synaptic turnover in non-denervated zones

C. Cotman, S. Scheff, S. Hoff, 1981, Brain Research.

Synapse repair in the hippocampus: the effects of aging.

C. Cotman, S. Hoff, 1983, Birth defects original article series.

Transmitter phenotype is a major determinant in the specificity of synapses formed by cholinergic neurons transplanted to the hippocampus

C. Cotman, R. Gibbs, K. Anderson, 1988, Neuroscience.

Short-Term Improvement on a Visual-Spatial Task After Music Listening in Alzheimer's Disease

C. Cotman, G. Shaw, Julene K. Johnson, 2002 .

Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors

C. Cotman, C. Peterson, 1990, Brain Research.

Specificity of Termination Fields Formed in the Developing Hippocampus by Fibers from Transplants

C. Cotman, 1984 .

PROTEINS OF THE POSTSYNAPTIC DENSITY

C. Cotman, G. Banker, L. Churchill, 1974, The Journal of cell biology.

Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion.

G. Lynch, C. Cotman, J. Nadler, 1973, Brain research.

Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging

C. Cotman, N. Milgram, B. Muggenburg, 2005 .

Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata

C. Cotman, J. Nadler, D. Shelton, 1979, Brain Research.

Induction of extensive fimbrial branching in the adult rat brain

C. Cotman, D. Goldowitz, 1978, Nature.

Increased spectrin proteolysis in the brindled mouse brain

Gary Lynch, Carl Cotman, G. Lynch, 1990, Neuroscience Letters.

Analysis of short-term plasticity at the perforant path-granule cell synapse

C. Cotman, J. Nadler, W. White, 1979, Brain Research.

Frontal Lobe Volume, Function, and β-Amyloid Pathology in a Canine Model of Aging

C. Cotman, N. Milgram, C. Siwak, 2004, The Journal of Neuroscience.

Frontal Lobe Volume , Function , and-Amyloid Pathology in a Canine Model of Aging

C. Cotman, N. Milgram, C. Siwak, 2004 .

The influence of the carboxyl terminus of the Alzheimer Aβ peptide on its conformation, aggregation, and neurotoxic properties

C. Cotman, C. Pike, R. Kayed, 2002, NeuroMolecular Medicine.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

C. Cotman, L. Breydo, R. Kayed, 2007, Molecular Neurodegeneration.

Lesion-induced alterations of lectin binding sites in the rat dentate gyrus

C. Cotman, D. Monaghan, E. Mena, 1981, Neuroscience.

ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN

C. Cotman, G. Banker, L. Churchill, 1974, The Journal of cell biology.

LOCALIZATION AND CHARACTERIZATION OF CONCANAVALIN A RECEPTORS IN THE SYNAPTIC CLEFT

C. Cotman, C. Cotman, D. Taylor, 1974, Journal of Cell Biology.

Subpopulations of dystrophic neurites [correction of neuritis] in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics.

Brian J Cummings, C. Cotman, J. Su, 1994, Brain research.

Effects of aging on NMDA and MK801 binding sites in mice

C. Cotman, K. Magnusson, 1993, Brain Research.

Learning deficits in rats with early neurotoxic lesions to the globus pallidus, substantia nigra, median raphe or pontine reticular formation

C. Cotman, Robert Thompson, R. Gibbs, 1986, Physiology & Behavior.

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

John X. Morris, Jason J. Corneveaux, Asha A. Nair, 2012, Neurology.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

C. Cotman, H. Paulson, V. Uversky, 2013, The Journal of clinical investigation.

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

C. Cotman, K. Intlekofer, 2013, Neurobiology of Disease.

Apolipoprotein E and Alzheimer’s Disease

Brian, Stanley, Anderton, 1996, Research and Perspectives in Alzheimer’s Disease.

Gene expression changes in the course of normal brain aging are sexually dimorphic

C. Cotman, J. Trojanowski, S. Heinemann, 2008, Proceedings of the National Academy of Sciences.

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

C. Cotman, E. Head, B. Michalski, 2012, Neurobiology of Aging.

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology.

Brian J Cummings, C. Cotman, C. Pike, 1992, Neuroreport.

Caspase-3 activation as a bifurcation point between plasticity and cell death

C. Cotman, Erica D. Smith, S. Snigdha, 2012, Neuroscience Bulletin.

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

C. Cotman, J. Geddes, I. Lott, 1986, Brain Research.

Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide

P. Kelly, C. Cotman, 1978, The Journal of cell biology.

Factors specifying the development of synapse number in the rat dentate gyrus: effects of partial target loss

C. Cotman, E. R. Lewis, 1980, Brain Research.

Chloride and calcium ions separate L-glutamate receptor populations in synaptic membranes.

G. Fagg, C. Cotman, A. Foster, 1983, European journal of pharmacology.

Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system

P. Kelly, C. Cotman, G. Nicolson, 1976, The Journal of cell biology.

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial.

C. Cotman, P. Johannsen, G. Waldemar, 2015, Journal of Alzheimer's disease : JAD.

Adenosine, l-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: interstimulus interval-dependent pharmacology

C. Cotman, J. Kahle, 2004, Experimental Brain Research.

Acidic Amino Acids as Excitatory Transmitters

C. Cotman, 1981 .

Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid.

C. Cotman, J. Emerson, M. Ibrahim, 1998, Investigative radiology.

Axonal sprouting at the neuromuscular junction of adult and aged rats

G. Fagg, C. Cotman, S. Scheff, 1981, Experimental Neurology.

Synthesis of [3H]2-Amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class ofl-glutamate binding sites

C. Cotman, D. Monaghan, A. Chamberlin, 1983, Brain Research.

LOCALIZATION AND CHARACTERIZATION OF CONCANAVALIN A RECEPTORS IN THE SYNAPTIC CLEFT

C. Cotman, Dwan A. Taylor, 1974, The Journal of cell biology.

Characteristics of Receptors for Excitatory Neurotransmitters

C. Cotman, 1984 .

Brain tissue transplantation research.

C. Cotman, E. Harris, 1984, Applied neurophysiology.

Differences in alkaline earth stimulation of neurotransmitter release from isolated brain synaptosomes

C. Cotman, J. Haycock, W. White, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.